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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 

Fibroblast growth factor-10 prevents H(2)O(2)- induced cell cycle arrest by regulation of G1 cyclins and cyclin dependent kinases.

We studied the effects of fibroblast growth factor (FGF-10) on H(2)O(2)-induced alveolar epithelial cell (AEC) G1 arrest and the role of G1 cyclins. FGF-10 prevented H(2)O(2)-induced AEC G1 arrest. FGF-10 induced 2-4-fold increase in cyclin E, cyclin A and CDKs (2,4) alone and in AEC treated with H(2)O(2). H(2)O(2) downregulated cyclin D1; FGF-10 blocked these effects. FGF-10 prevented H(2)O(2)- induced upregulation of CDK inhibitor, p21. SiRNAp21 blocked H(2)O(2)-induced downregulation of cyclins, CDKs and AEC G1 arrest. Accordingly, we provide first evidence that FGF-10 regulates G1 cyclins and CDKs, and prevents H(2)O(2)-induced AEC G1 arrest.[1]

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