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Gene Review

FGF10  -  fibroblast growth factor 10

Homo sapiens

Synonyms: FGF-10, Fibroblast growth factor 10, Keratinocyte growth factor 2
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Disease relevance of FGF10


High impact information on FGF10

  • FGF7 and FGF10 activate only the b isoform of FGFR2 (FGFR2b) [5].
  • Structure-based mutagenesis of FGF10 confirms the importance of the observed contacts for FGF10 biological activity [5].
  • Unique contacts between divergent regions in FGF10 and two b-specific loops in D3 reveal the structural basis by which alternative splicing provides FGF10-FGFR2b specificity [5].
  • In some cases, marked HOX overexpression was associated with elevated FGF10 and FGF17 [6].
  • Highly similar lung and limb phenotypes were detected recently in the loss of function mutation of Fgf10, a ligand of Fgfr2 [7].

Chemical compound and disease context of FGF10


Biological context of FGF10


Anatomical context of FGF10


Associations of FGF10 with chemical compounds


Regulatory relationships of FGF10


Other interactions of FGF10


Analytical, diagnostic and therapeutic context of FGF10


  1. Proline to arginine mutations in FGF receptors 1 and 3 result in Pfeiffer and Muenke craniosynostosis syndromes through enhancement of FGF binding affinity. Ibrahimi, O.A., Zhang, F., Eliseenkova, A.V., Linhardt, R.J., Mohammadi, M. Hum. Mol. Genet. (2004) [Pubmed]
  2. Expression of fibroblast growth factor (FGF)-10 in human colorectal adenocarcinoma cells. Matsuike, A., Ishiwata, T., Watanabe, M., Asano, G. Journal of Nippon Medical School = Nihon Ika Daigaku zasshi. (2001) [Pubmed]
  3. Activation of mitogen-activated protein kinase pathway by keratinocyte growth factor or fibroblast growth factor-10 promotes cell proliferation in human endometrial carcinoma cells. Taniguchi, F., Harada, T., Sakamoto, Y., Yamauchi, N., Yoshida, S., Iwabe, T., Terakawa, N. J. Clin. Endocrinol. Metab. (2003) [Pubmed]
  4. Immunohistochemical analysis of keratinocyte growth factor and fibroblast growth factor 10 expression in psoriasis. Kovacs, D., Falchi, M., Cardinali, G., Raffa, S., Carducci, M., Cota, C., Amantea, A., Torrisi, M.R., Picardo, M. Exp. Dermatol. (2005) [Pubmed]
  5. Structural basis by which alternative splicing confers specificity in fibroblast growth factor receptors. Yeh, B.K., Igarashi, M., Eliseenkova, A.V., Plotnikov, A.N., Sher, I., Ron, D., Aaronson, S.A., Mohammadi, M. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  6. Altered HOX and WNT7A expression in human lung cancer. Calvo, R., West, J., Franklin, W., Erickson, P., Bemis, L., Li, E., Helfrich, B., Bunn, P., Roche, J., Brambilla, E., Rosell, R., Gemmill, R.M., Drabkin, H.A. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  7. Fgfr2 is required for limb outgrowth and lung-branching morphogenesis. Arman, E., Haffner-Krausz, R., Gorivodsky, M., Lonai, P. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  8. Structure and expression of human fibroblast growth factor-10. Emoto, H., Tagashira, S., Mattei, M.G., Yamasaki, M., Hashimoto, G., Katsumata, T., Negoro, T., Nakatsuka, M., Birnbaum, D., Coulier, F., Itoh, N. J. Biol. Chem. (1997) [Pubmed]
  9. Fibroblast growth factor receptor 2 tyrosine kinase is required for prostatic morphogenesis and the acquisition of strict androgen dependency for adult tissue homeostasis. Lin, Y., Liu, G., Zhang, Y., Hu, Y.P., Yu, K., Lin, C., McKeehan, K., Xuan, J.W., Ornitz, D.M., Shen, M.M., Greenberg, N., McKeehan, W.L., Wang, F. Development (2007) [Pubmed]
  10. FGFR2, FGF8, FGF10 and BMP7 as candidate genes for hypospadias. Beleza-Meireles, A., Lundberg, F., Lagerstedt, K., Zhou, X., Omrani, D., Frisén, L., Nordenskjöld, A. Eur. J. Hum. Genet. (2007) [Pubmed]
  11. KGF and FGF-10 stimulate liquid secretion in human fetal lung. Graeff, R.W., Wang, G., McCray, P.B. Pediatr. Res. (1999) [Pubmed]
  12. Effect of nitric oxide on fibroblast growth factor-10 and bone morphogenetic protein 4 expressions in the branching morphogenesis of fetal rat lung explants. Shinkai, M., Shinkai, T., Pirker, M.A., Montedonico, S., Puri, P. J. Pediatr. Surg. (2005) [Pubmed]
  13. FGF-10 is expressed at low levels in the human prostate. Ropiquet, F., Giri, D., Kwabi-Addo, B., Schmidt, K., Ittmann, M. Prostate (2000) [Pubmed]
  14. Fibroblast growth factors 7 and 10 are expressed in the human embryonic pancreatic mesenchyme and promote the proliferation of embryonic pancreatic epithelial cells. Ye, F., Duvillié, B., Scharfmann, R. Diabetologia (2005) [Pubmed]
  15. Fibroblast growth factor 10 induces proliferation and differentiation of human primary cultured keratinocytes. Marchese, C., Felici, A., Visco, V., Lucania, G., Igarashi, M., Picardo, M., Frati, L., Torrisi, M.R. J. Invest. Dermatol. (2001) [Pubmed]
  16. Mast cell-fibroblast interactions: human mast cells as source and inducers of fibroblast and epithelial growth factors. Artuc, M., Steckelings, U.M., Henz, B.M. J. Invest. Dermatol. (2002) [Pubmed]
  17. Fibroblast growth factor-10 attenuates H2O2-induced alveolar epithelial cell DNA damage: role of MAPK activation and DNA repair. Upadhyay, D., Bundesmann, M., Panduri, V., Correa-Meyer, E., Kamp, D.W. Am. J. Respir. Cell Mol. Biol. (2004) [Pubmed]
  18. Fibroblast growth factor-10 prevents H(2)O(2)-induced cell cycle arrest by regulation of G1 cyclins and cyclin dependent kinases. Upadhyay, D., Chang, W., Wei, K., Gao, M., Rosen, G.D. FEBS Lett. (2007) [Pubmed]
  19. Of worms and men: an evolutionary perspective on the fibroblast growth factor (FGF) and FGF receptor families. Coulier, F., Pontarotti, P., Roubin, R., Hartung, H., Goldfarb, M., Birnbaum, D. J. Mol. Evol. (1997) [Pubmed]
  20. Expression and regulation of Sprouty-2 in the granulosa-lutein cells of the corpus luteum. Haimov-Kochman, R., Ravhon, A., Prus, D., Greenfield, C., Finci-Yeheskel, Z., S Goldman-Wohl, D., Natanson-Yaron, S., Reich, R., Yagel, S., Hurwitz, A. Mol. Hum. Reprod. (2005) [Pubmed]
  21. Fibroblast growth factor-10 and fibroblast growth factor receptors 1-4: expression and peptide localization in human decidua and placenta. Anteby, E.Y., Natanson-Yaron, S., Hamani, Y., Sciaki, Y., Goldman-Wohl, D., Greenfield, C., Ariel, I., Yagel, S. Eur. J. Obstet. Gynecol. Reprod. Biol. (2005) [Pubmed]
  22. Biochemical analysis of pathogenic ligand-dependent FGFR2 mutations suggests distinct pathophysiological mechanisms for craniofacial and limb abnormalities. Ibrahimi, O.A., Zhang, F., Eliseenkova, A.V., Itoh, N., Linhardt, R.J., Mohammadi, M. Hum. Mol. Genet. (2004) [Pubmed]
  23. Restoration of fibroblast growth factor receptor2 suppresses growth and tumorigenicity of malignant human prostate carcinoma PC-3 cells. Yasumoto, H., Matsubara, A., Mutaguchi, K., Usui, T., McKeehan, W.L. Prostate (2004) [Pubmed]
  24. Regulation of FGF10 by POU transcription factor Brn3a in the developing trigeminal ganglion. Cox, E., Lanier, J., Quina, L., Eng, S.R., Turner, E.E. J. Neurobiol. (2006) [Pubmed]
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