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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Effects of cilazaprilat and enalaprilat on experimental dermatitis in guinea pigs.

Two non-sulfur containing ACE-inhibitors were tested concerning their local effect on experimental dermatitis in ovalbumin-sensitized guinea pigs. Enalaprilat but not cilazaprilat potentiated the ovalbumin-evoked inflammatory response. Furthermore, enalaprilat clearly enhanced the erythema evoked by substance P, whereas cilazaprilat did not. Concerning, the bradykinin-evoked erythema, enalaprilat significantly potentiated the response, whereas cilazaprilat only caused a slight increase. Our results suggest that different affinities for peptidases involved in degradation of inflammatory peptides can explain differences between the pro-inflammatory properties of enalaprilat and cilazaprilat.[1]

References

  1. Effects of cilazaprilat and enalaprilat on experimental dermatitis in guinea pigs. Rosenqvist, U., Persson, K., Lindgren, B.R., Andersson, R.G. Pharmacol. Toxicol. (1991) [Pubmed]
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