Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Ibáñez, L. et al.

Lourdes Ibáñez, Abel Lopez-Bermejo, Larisa Suárez, Maria Victoria Marcos, Marta Díaz, Francis de Zegher,

Visceral adiposity without overweight in children born small for gestational age.

CONTEXT: Children born small for gestational age (SGA) tend to develop catch-up growth in infancy and become overweight by the age of 6 yr. Weight control is advocated as a preventive measure, but it is unknown whether such control suffices to prevent visceral fat excess and hypoadiponectinemia. SETTING: The study was performed at a university hospital. STUDY POPULATION AND DESIGN: A total of 64 children (32 matched pairs) aged 6 yr, of whom 32 were born appropriate for gestational age and 32 were born SGA, and had subsequently developed spontaneous catch-up growth were included in the study; matching was performed for gender, height, weight, and, thus, body mass index. MAIN OUTCOMES: Fasting insulin, IGF-I, high molecular weight adiponectin, leptin, visfatin, and lean and fat mass were calculated by absorptiometry, and abdominally sc and visceral fat by magnetic resonance imaging. RESULTS: After strict matching, SGA children had a total lean mass, total fat mass, leptinemia, and visfatinemia comparable to those in the appropriate for gestational age children, but they still had higher fasting insulin and IGF-I levels (P < 0.01), much lower high molecular weight adiponectin levels (P < 0.0001), and a striking shift from abdominally sc to visceral fat (P < 0.0001). Fasting insulin (r = 0.52; P < 0.00001) was a major determinant of visceral fat in boys and girls, explaining 28% of its variance. CONCLUSIONS: SGA children tend to be viscerally adipose and hypo-adiponectinemic, even if they are not overweight. Therefore, measures beyond weight control seem to be needed to allow most SGA children to normalize their body composition and endocrine-metabolic homeostasis.[1]

References

Visceral adiposity without overweight in children born small for gestational age. Ibáñez, L., Lopez-Bermejo, A., Suárez, L., Marcos, M.V., Díaz, M., de Zegher, F. J. Clin. Endocrinol. Metab. (2008) [Pubmed]

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