Coronary thrombosis in a patient with May-Hegglin anomaly.
May-Hegglin anomaly ( MHA) is a rare hereditary condition that is characterized by cytoplasmic inclusions in leukocytes and giant platelets. Many patients have some degree of thrombocytopenia. Most individuals with MHA are asymptomatic, but 25-43% of patients previously reported have had a hemorrhagic tendency. The authors describe a patient with MHA who had no history of hemorrhage but who developed complete coronary thrombosis after attempted angioplasty despite an apparent platelet count of 24,000 per mm3. Laboratory investigations revealed a normal bleeding time, normal platelet aggregation, and an increase in the size of approximately two-thirds of the platelets. The calculated platelet mass was near normal, which probably explains the thrombosis despite a decrease in platelet numbers. The authors conclude that in some patients with MHA platelets are functionally active both in vivo and in vitro.[1]References
- Coronary thrombosis in a patient with May-Hegglin anomaly. McDunn, S., Hartz, W., Ts'Ao, C., Green, D. Am. J. Clin. Pathol. (1991) [Pubmed]
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