Distribution and function of brain natriuretic peptide in the stomach and small intestine of the rat.
The distribution and function of brain natriuretic peptide ( BNP) was studied in the rat stomach and jejunum. BNP-like immunoreactive nerves were found in the myenteric plexus, circular muscle, submucosa and in the crypt region of the jejunum. In the stomach, BNP-like immunoreactivity was found in the myenteric plexus, circular muscle, submucosa and at the base of the gastric glands. In the submucosa, BNP-like immunoreactivity was often associated with blood vessels. In segments of rat jejunum mounted in Ussing chambers, serosal exposure to rat BNP caused a concentration-dependent increase in short circuit current. A maximal effect of 18 +/- 4 microA/cm2 was observed with 1 microM BNP. The effect was quantitatively and qualitatively similar to that elicited by serosal exposure to equimolar atrial natriuretic peptide. The response to BNP was reduced by 88% in chloride free Kreb's buffer, by 83% in tissues pretreated with cinanserin, an antagonist of the 5-HT2 subtype of the 5-hydroxytryptamine receptor, and by 96% in tissues pretreated with tetrodotoxin, a blocker of axonal conduction. These results are consistent with a physiological role for BNP as a neuromodulator of gastrointestinal electrolyte transport.[1]References
- Distribution and function of brain natriuretic peptide in the stomach and small intestine of the rat. Sharkey, K.A., Gall, D.G., MacNaughton, W.K. Regul. Pept. (1991) [Pubmed]
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