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Cloning of fish zinc-finger genes related to Krox-20 and Krox-24.

Southern hybridization suggests that the zebrafish genome contains multiple zinc-finger genes related to the putative mouse developmental genes, Krox-20 and Krox-24. The polymerase chain reaction was employed to amplify and clone the zinc-finger regions of genes related to Krox-20, from two fish species and, for comparison, mouse, hamster and fox. DNA sequence analyses suggest that the genes cloned include the guppy homologue of Krox-20 and the zebrafish homologue of Krox-24, and that these genes diverged prior to the separation of the lineages leading to teleosts and to mammals.[1]

References

  1. Cloning of fish zinc-finger genes related to Krox-20 and Krox-24. Lanfear, J., Jowett, T., Holland, P.W. Biochem. Biophys. Res. Commun. (1991) [Pubmed]
 
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