Gene Review:
Egr2 - early growth response 2
Mus musculus
Synonyms:
E3 SUMO-protein ligase EGR2, EGR-2, Early growth response protein 2, Egr-2, Krox-20, ...
- The segment-specific gene Krox-20 encodes a transcription factor with binding sites in the promoter region of the Hox-1.4 gene. Chavrier, P., Vesque, C., Galliot, B., Vigneron, M., Dollé, P., Duboule, D., Charnay, P. EMBO J. (1990)
- Disruption of Krox-20 results in alteration of rhombomeres 3 and 5 in the developing hindbrain. Schneider-Maunoury, S., Topilko, P., Seitandou, T., Levi, G., Cohen-Tannoudji, M., Pournin, S., Babinet, C., Charnay, P. Cell (1993)
- Reorganization of pontine rhythmogenic neuronal networks in Krox-20 knockout mice. Jacquin, T.D., Borday, V., Schneider-Maunoury, S., Topilko, P., Ghilini, G., Kato, F., Charnay, P., Champagnat, J. Neuron (1996)
- Retinoic acid alters hindbrain Hox code and induces transformation of rhombomeres 2/3 into a 4/5 identity. Marshall, H., Nonchev, S., Sham, M.H., Muchamore, I., Lumsden, A., Krumlauf, R. Nature (1992)
- Segment-specific expression of a zinc-finger gene in the developing nervous system of the mouse. Wilkinson, D.G., Bhatt, S., Chavrier, P., Bravo, R., Charnay, P. Nature (1989)
- Perinatal lethality and defects in hindbrain development in mice homozygous for a targeted mutation of the zinc finger gene Krox20. Swiatek, P.J., Gridley, T. Genes Dev. (1993)
- Identification of NAB1, a repressor of NGFI-A- and Krox20-mediated transcription. Russo, M.W., Sevetson, B.R., Milbrandt, J. Proc. Natl. Acad. Sci. U.S.A. (1995)
- Local alterations of Krox-20 and Hox gene expression in the hindbrain suggest lack of rhombomeres 4 and 5 in homozygote null Hoxa-1 (Hox-1.6) mutant embryos. Dollé, P., Lufkin, T., Krumlauf, R., Mark, M., Duboule, D., Chambon, P. Proc. Natl. Acad. Sci. U.S.A. (1993)
- Segmental expression of Hoxa-2 in the hindbrain is directly regulated by Krox-20. Nonchev, S., Vesque, C., Maconochie, M., Seitanidou, T., Ariza-McNaughton, L., Frain, M., Marshall, H., Sham, M.H., Krumlauf, R., Charnay, P. Development (1996)
- Regulation of cholesterol/lipid biosynthetic genes by Egr2/Krox20 during peripheral nerve myelination. Leblanc, S.E., Srinivasan, R., Ferri, C., Mager, G.M., Gillian-Daniel, A.L., Wrabetz, L., Svaren, J. J. Neurochem. (2005)
- Egr-2 and Egr-3 are negative regulators of T cell activation. Safford, M., Collins, S., Lutz, M.A., Allen, A., Huang, C.T., Kowalski, J., Blackford, A., Horton, M.R., Drake, C., Schwartz, R.H., Powell, J.D. Nat. Immunol. (2005)
- Glucocorticoids inhibit osteocalcin transcription in osteoblasts by suppressing Egr2/Krox20-binding enhancer. Leclerc, N., Noh, T., Khokhar, A., Smith, E., Frenkel, B. Arthritis Rheum. (2005)
- c-jun regulation and function in the developing hindbrain. Mechta-Grigoriou, F., Giudicelli, F., Pujades, C., Charnay, P., Yaniv, M. Dev. Biol. (2003)
- Gene expression profiling of glucocorticoid-inhibited osteoblasts. Leclerc, N., Luppen, C.A., Ho, V.V., Nagpal, S., Hacia, J.G., Smith, E., Frenkel, B. J. Mol. Endocrinol. (2004)
- Krox-20 is a key regulator of rhombomere-specific gene expression in the developing hindbrain. Seitanidou, T., Schneider-Maunoury, S., Desmarquet, C., Wilkinson, D.G., Charnay, P. Mech. Dev. (1997)
- Induction of the early growth response (Egr) family of transcription factors during thymic selection. Shao, H., Kono, D.H., Chen, L.Y., Rubin, E.M., Kaye, J. J. Exp. Med. (1997)
- Krox-20 inhibits Jun-NH2-terminal kinase/c-Jun to control Schwann cell proliferation and death. Parkinson, D.B., Bhaskaran, A., Droggiti, A., Dickinson, S., D'Antonio, M., Mirsky, R., Jessen, K.R. J. Cell Biol. (2004)
- Progesterone stimulates Krox-20 gene expression in Schwann cells. Guennoun, R., Benmessahel, Y., Delespierre, B., Gouézou, M., Rajkowski, K.M., Baulieu, E.E., Schumacher, M. Brain Res. Mol. Brain Res. (2001)
- Characterisation of cis-acting sequences reveals a biphasic, axon-dependent regulation of Krox20 during Schwann cell development. Ghislain, J., Desmarquet-Trin-Dinh, C., Jaegle, M., Meijer, D., Charnay, P., Frain, M. Development (2002)
- Hoxb-2 transcriptional activation in rhombomeres 3 and 5 requires an evolutionarily conserved cis-acting element in addition to the Krox-20 binding site. Vesque, C., Maconochie, M., Nonchev, S., Ariza-McNaughton, L., Kuroiwa, A., Charnay, P., Krumlauf, R. EMBO J. (1996)
- The kreisler mouse: a hindbrain segmentation mutant that lacks two rhombomeres. McKay, I.J., Muchamore, I., Krumlauf, R., Maden, M., Lumsden, A., Lewis, J. Development (1994)
- Vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide inhibit expression of Fas ligand in activated T lymphocytes by regulating c-Myc, NF-kappa B, NF-AT, and early growth factors 2/3. Delgado, M., Ganea, D. J. Immunol. (2001)
- Rostral hindbrain patterning involves the direct activation of a Krox20 transcriptional enhancer by Hox/Pbx and Meis factors. Wassef, M.A., Chomette, D., Pouilhe, M., Stedman, A., Havis, E., Desmarquet-Trin Dinh, C., Schneider-Maunoury, S., Gilardi-Hebenstreit, P., Charnay, P., Ghislain, J. Development (2008)
- Key roles of retinoic acid receptors alpha and beta in the patterning of the caudal hindbrain, pharyngeal arches and otocyst in the mouse. Dupé, V., Ghyselinck, N.B., Wendling, O., Chambon, P., Mark, M. Development (1999)
- Altered rhombomere-specific gene expression and hyoid bone differentiation in the mouse segmentation mutant, kreisler (kr). Frohman, M.A., Martin, G.R., Cordes, S.P., Halamek, L.P., Barsh, G.S. Development (1993)
- Two mouse genes encoding potential transcription factors with identical DNA-binding domains are activated by growth factors in cultured cells. Lemaire, P., Revelant, O., Bravo, R., Charnay, P. Proc. Natl. Acad. Sci. U.S.A. (1988)
- Hindbrain patterning: Krox20 couples segmentation and specification of regional identity. Voiculescu, O., Taillebourg, E., Pujades, C., Kress, C., Buart, S., Charnay, P., Schneider-Maunoury, S. Development (2001)
- Exposure to retinoic acid before or after the onset of somitogenesis reveals separate effects on rhombomeric segmentation and 3' HoxB gene expression domains. Wood, H., Pall, G., Morriss-Kay, G. Development (1994)