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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Cloning and characterization of a protein binding to the J kappa recombination signal sequence of immunoglobulin genes.

A protein with molecular weight of 60,000 that binds to the recombination signal sequence (RS) of the immunoglobulin J kappa segment was purified from the nuclear extract of a murine pre B cell line 38B9. This binding protein was found in lymphoid cell lines but not in non-lymphoid cell lines. The Kd value of the J kappa RS binding protein to the J kappa RS was 1 nM. The cDNA clone (RBP-2) was isolated based on partial amino-acid sequence of this protein. This cDNA encodes 526 amino-acid residues, and its sequence does not show extensive overall homology with any known proteins, but displays an interesting homology to a 40-residue region that is conserved among a subset of site specific recombinase (integrase family).[1]

References

  1. Cloning and characterization of a protein binding to the J kappa recombination signal sequence of immunoglobulin genes. Hamaguchi, Y., Mastunami, N., Yamamoto, Y., Kuze, K., Kangawa, K., Matsuo, H., Kawaichi, M., Honjo, T. Adv. Exp. Med. Biol. (1991) [Pubmed]
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