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Wang, Y. et al.

Youhua Wang, Dawei Xu, Ran Tao, Hairong Wang, Qiuhong Wang, Aiguo Shen,

β1,4-Galactosyltransferase-I contributes to the inflammatory processes in synovial tissue of patients with rheumatoid arthritis.

OBJECTIVE AND DESIGN: The aim of the study is to examine the expression and possible biological function of β1,4-galactosyltransferase-I (β1,4-GalT-I) in synovial tissue from rheumatoid arthritis (RA) patients. METHODS: Synovial tissue samples from twelve RA patients were stained for β1,4-GalT-I. Samples from seven patients with osteoarthritis (OA) and eight healthy people were obtained as controls. Real-time PCR or western blot analysis was used to observe the expression of β1,4-GalT-I and E-selectin. Cellular colocalization of β1,4-GalT-I, galactose-containing glycans and other molecules was analyzed by double immunofluorescence. RESULTS: Expression of β1,4-GalT-I and galactose-containing glycans increased in synovial tissue of RA patients compared with OA patients and healthy controls. Most galactose-containing glycans and β1,4-GalT-I were expressed in inflammatory cells. E-selectin overexpressed and was correlated with galactose-containing glycans in RA synovial tissue. CONCLUSION: These results suggested that β1,4-GalT-I may play an important role in the inflammatory processes in synovial tissue of patients with rheumatoid arthritis.[1]

References

β1,4-Galactosyltransferase-I contributes to the inflammatory processes in synovial tissue of patients with rheumatoid arthritis. Wang, Y., Xu, D., Tao, R., Wang, H., Wang, Q., Shen, A. Inflamm. Res. (2010) [Pubmed]

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