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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Compensation of progressive hypercapnia in the toad (Bufo marinus) and the bullfrog (Rana catesbeiana).

Toads (Bufo marinus L.) and bullfrogs (Rana catesbeiana Shaw) were subjected to a series of 24 h step increases in aerial CO2 (2, 4, 6 and 8%) to assess the degree of extracellular pH compensation at each CO2 level and to ascertain the importance of cutaneous ion transport in this process. Elevation of plasma [HCO3-] occurs during the 24 h period, with the bullfrogs showing a greater ability to compensate at each step. There was no indication that a [HCO3-] threshold of 30 mmol l-1 existed in either species, although bullfrogs appeared to have a greater compensatory potential when exposed to the higher levels of CO2. The results of the ion flux experiments suggest that neither the terrestrial Bufo nor the semi-aquatic Rana use their skin to any great extent for acid-base balance during hypercapnia.[1]

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