Relationship between ACTH secretion and corticoid binding to specific receptors in perifused adenohypophyses.
This study reports on the kinetics of glucocorticoid-induced inhibition of ACTH release, together with steroid binding to specific pituitary receptors. It was shown that corticosterone (CORT) inhibited ACTH output provoked by either corticotropin-releasing factor ( CRF) extracts or dbcAMP, in a manner which was both dose- and time-dependent. A close correlation appeared to exist between the degree of ACTH blockade and the percentage of filled steroid-binding sites. However, exposure of hypophyses to CORT for a critical period of time was a prerequisite for such a relationship to develop. Furthermore, it was found that dexamethasone (DEX) was more potent than CORT in inhibiting ACTH secretion and, in addition, bound to a greater extent to nuclei of pituitary cells. These data suggest the existence of a close correlation between occupancy of pituitary glucocorticoid receptors and modulation of ACTH secretion.[1]References
- Relationship between ACTH secretion and corticoid binding to specific receptors in perifused adenohypophyses. Koch, B., Lutz-Bucher, B., Briaud, B., Mialhe, C. Neuroendocrinology (1979) [Pubmed]
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