The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

2-Bromoethanamine nephrotoxicity in the nude mouse: an atypical targetting for the renal cortex.

Male MF1-nu/nu/Ola/ Hsd nude mice, maintained in a gnotobiotic environment, were dosed i.p. with either 50, 100 or 200 mg/kg 2-bromoethanamine (BEA) hydrobromide to induce a model papillary necrosis. Renal histological changes were examined in semithin glycolmethacrylate resin sections at 24, 48 and 72 h after BEA treatment. The sequence of medullary changes included pyknosis of interstitial cell nuclei, increased staining of the interstitial mucopolysaccharide matrix, platelets adhering to capillary endothelium, necrosis of collecting duct epithelial cells and denudation of the covering epithelium of the papilla. This was similar to that previously described in the Wistar rat, but the time course was extended. There was also a concomitant and extensive cortical necrosis of the P2 and P3 segments of the proximal tubule, which was evident prior to the onset of renal papillary necrosis at the higher doses of BEA. Nude mice show an atypical response to BEA compared to several mouse and rat strains, the hamster and pig, that suggests unique characteristics in this athymic murine mutant.[1]


  1. 2-Bromoethanamine nephrotoxicity in the nude mouse: an atypical targetting for the renal cortex. Gregg, N.J., Bach, P.H. International journal of experimental pathology. (1990) [Pubmed]
WikiGenes - Universities