The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

AGN-PC-0CVO0Q     2-bromoethanamine

Synonyms: AG-C-21337, CHEMBL1697693, LS-67939, CTK0H3575, SBB005857, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of NSC3406


High impact information on NSC3406


Chemical compound and disease context of NSC3406


Biological context of NSC3406


Anatomical context of NSC3406

  • These data suggest that changes in the medullary matrix might play a previously unrecognized role in the development of 2-bromoethanamine hydrobromide-induced renal papillary necrosis, and these changes may give rise to loss of the material that supports the medullary capillaries [17].
  • Hexachlorobutadiene-N-acetylcysteine (HCBD-NAC), adriamycin and 2-bromoethanamine hydrobromide are three renal toxins that have shown in vivo a highly selective target cell toxicity--to the proximal tubules, the glomerular epithelial cells and the medullary interstitial cells, respectively [18].

Associations of NSC3406 with other chemical compounds


Gene context of NSC3406

  • 2-bromoethylamine has been recently developed with a potent, selective and suicide SSAO inhibitor without any inhibitory effect on MAO activity Using this inhibitor, it is possible to study the role of the enzyme in mammalian tissues [24].
  • A keratin sponge was chemically modified to obtain carboxyl and amino sponges by the alkylation of a large amount of active SH group on keratin proteins with iodoacetic acid and 2-bromoethylamine, respectively [25].

Analytical, diagnostic and therapeutic context of NSC3406


  1. The renal antihypertensive effect of angiotensin I converting enzyme inhibitors. Matsukawa, S., Suzuki, H., Itaya, Y., Kumagai, H., Saruta, T. J. Hypertens. (1987) [Pubmed]
  2. Rabies virus inactivation by binary ethylenimine: new method for inactivated vaccine production. Larghi, O.P., Nebel, A.E. J. Clin. Microbiol. (1980) [Pubmed]
  3. Evidence for a decreased noradrenaline sensitivity in mesenteric resistance vessels from rats with chemical renal medullectomy. Bund, S.J., Heagerty, A.M., Fletcher, A., Swales, J.D. Clin. Sci. (1989) [Pubmed]
  4. Selective renal medullary damage and hypertension in the rat: the role of vasopressin. Russell, G.I., Godfrey, N.P., Forsling, M.L., Bing, R.F., Thurston, H., Swales, J.D. Clin. Sci. (1986) [Pubmed]
  5. Prediction of nephrotoxicant action and identification of candidate toxicity-related biomarkers. Thukral, S.K., Nordone, P.J., Hu, R., Sullivan, L., Galambos, E., Fitzpatrick, V.D., Healy, L., Bass, M.B., Cosenza, M.E., Afshari, C.A. Toxicologic pathology. (2005) [Pubmed]
  6. The critical active-site amine of the human 8-oxoguanine DNA glycosylase, hOgg1: direct identification, ablation and chemical reconstitution. Nash, H.M., Lu, R., Lane, W.S., Verdine, G.L. Chem. Biol. (1997) [Pubmed]
  7. Nuclear magnetic resonance spectroscopy and pattern recognition analysis of the biochemical processes associated with the progression of and recovery from nephrotoxic lesions in the rat induced by mercury(II) chloride and 2-bromoethanamine. Holmes, E., Bonner, F.W., Sweatman, B.C., Lindon, J.C., Beddell, C.R., Rahr, E., Nicholson, J.K. Mol. Pharmacol. (1992) [Pubmed]
  8. Role of renal papillae in the regulation of sodium excretion during acute elevation of renal perfusion pressure in the rat. Chen, P.S., Caldwell, R.M., Hsu, C.H. Hypertension (1984) [Pubmed]
  9. Detection of diffuse glomerular lesions in rats: II. Comparison of indium-111 cationic small macromolecules with technetium-99m DTPA. McAfee, J.G., Thomas, F.D., Subramanian, G., Schneider, R.D., Lyons, B., Roskopf, M., Zapf-Longo, C., Whaley, D. J. Nucl. Med. (1986) [Pubmed]
  10. 2-Bromoethylamine as a potent selective suicide inhibitor for semicarbazide-sensitive amine oxidase. Yu, P.H., Davis, B.A., Deng, Y. Biochem. Pharmacol. (2001) [Pubmed]
  11. Hypertension produced by chemical renal medullectomy: evidence for a renomedullary vasodepressor function in the rat. Taverner, D., Bing, R.F., Fletcher, A., Russell, G., Swales, J.D., Thurston, H. Clin. Sci. (1984) [Pubmed]
  12. Variability in the renal clearance of cephalexin in experimental renal failure. Maïza, A., Daley-Yates, P.T. Journal of pharmacokinetics and biopharmaceutics. (1993) [Pubmed]
  13. Renal response to atrial natriuretic factor in rats without intact papillae. Torikai, S. Clin. Sci. (1986) [Pubmed]
  14. 2-Bromoethanamine nephrotoxicity in the nude mouse: an atypical targetting for the renal cortex. Gregg, N.J., Bach, P.H. International journal of experimental pathology. (1990) [Pubmed]
  15. Effect of bromoethylamine hydrobromide on systemic acid-base balance. Nakamura, Y., Sasaki, S., Shigai, T., Marumo, F. Tohoku J. Exp. Med. (1988) [Pubmed]
  16. Natriuretic response to hypervolemia is absent in rats with papillary necrosis. Keeler, R., Wilson, N. Am. J. Physiol. (1989) [Pubmed]
  17. Changes in medullary glycosaminoglycan histochemistry and microvascular filling during the development of 2-bromoethanamine hydrobromide-induced renal papillary necrosis. Bach, P.H., Grasso, P., Molland, E.A., Bridges, J.W. Toxicol. Appl. Pharmacol. (1983) [Pubmed]
  18. The mechanisms of target cell injury by nephrotoxins. Bach, P.H., Ketley, C.P., Ahmed, I., Dixit, M. Food Chem. Toxicol. (1986) [Pubmed]
  19. Site-directed mutagenesis of active site residues of phosphite dehydrogenase. Woodyer, R., Wheatley, J.L., Relyea, H.A., Rimkus, S., van der Donk, W.A. Biochemistry (2005) [Pubmed]
  20. The application of proton nuclear magnetic resonance imaging for the in vivo characterisation of chemically induced renal lesions in rats over a prolonged time study. Finney, J.S., Bach, P.H., Bushell, M.C., Gregg, N.M., Taylor, D.G. Magnetic resonance imaging. (1990) [Pubmed]
  21. Inhibition of tissue-bound semicarbazide-sensitive amine oxidase by two haloamines, 2-bromoethylamine and 3-bromopropylamine. Kinemuchi, H., Kobayashi, N., Takahashi, K., Takayanagi, K., Arai, Y., Tadano, T., Kisara, K., Oreland, L. Arch. Biochem. Biophys. (2001) [Pubmed]
  22. Arachidonic-acid-dependent metabolism of 2-bromoethanamine to a toxic metabolite in rat medullary interstitial cell cultures. Grieve, E.M., Whiting, P.H., Hawksworth, G.M. Toxicol. Lett. (1990) [Pubmed]
  23. Effects of reserpine and L-cysteine and glutathione depletion on 2-bromoethylamine hydrobromide-induced tubular necrosis in Swiss ICR mice. Wolf, D.C., Carlson, G.P., DeNicola, D.B., Carlton, W.W. Food Chem. Toxicol. (1991) [Pubmed]
  24. Selective inhibitors of membrane-bound semicarbazide-sensitive amine oxidase (SSAO) activity in mammalian tissues. Kinemuchi, H., Sugimoto, H., Obata, T., Satoh, N., Ueda, S. Neurotoxicology (2004) [Pubmed]
  25. Modified keratin sponge: Binding of bone morphogenetic protein-2 and osteoblast differentiation. Tachibana, A., Nishikawa, Y., Nishino, M., Kaneko, S., Tanabe, T., Yamauchi, K. J. Biosci. Bioeng. (2006) [Pubmed]
  26. Evidence for a renomedullary vasodepressor system in rabbits and dogs. Christy, I.J., Woods, R.L., Courneya, C.A., Denton, K.M., Anderson, W.P. Hypertension (1991) [Pubmed]
  27. Role of the renal medulla in adrenocorticotrophin-induced hypertension in rats. Li, M., Birchall, I., Kincaid-Smith, P.S., Whitworth, J.A. J. Hypertens. (1992) [Pubmed]
  28. Experimental renal papillary necrosis in rats: microangiographic and tubular micropuncture injection studies. Cuttino, J.T., Goss, F.U., Clark, R.L., Marr, M.C. Investigative radiology. (1981) [Pubmed]
  29. Early sequential ultrastructural renal alterations induced by 2-bromoethylamine hydrobromide in the Swiss ICR mouse. Wolf, D.C., Turek, J.J., Carlton, W.W. Vet. Pathol. (1992) [Pubmed]
  30. Effect of atrial natriuretic factor on renal function in rats with papillary necrosis. Hildebrandt, D.A., Banks, R.O. Am. J. Physiol. (1987) [Pubmed]
WikiGenes - Universities