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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Complement gene expression in hepatic and extrahepatic tissues of NZB and NZB x W (F1) mouse strains.

To study the role of local production of complement proteins during the evolution of a naturally occurring immune complex disease, C3, C4, C2 and Factor B mRNA expression was assessed in several tissues of the inbred mouse strains NZB and (NZB x W) F1 hybrid. In the NZB/W F1 hybrid strain, coincident with the development of glomerulonephritis a marked increase in kidney C3 and C4 mRNA was observed; Factor B mRNA, which is expressed as a doublet in kidney and intestine, showed an increase in expression of the smaller transcript. This alteration of kidney C3, C4 and Factor B mRNA is identical to that noted in association with lupus nephritis in the MRL lpr/lpr strain and following in vivo administration of endotoxin to the BALB/c strain. The development of systemic lupus erythematosis (SLE) in the NZB/W F1 was not associated with a marked change in hepatic complement gene expression. These findings support the hypothesis that local production of complement may play a role in the pathogenesis of glomerulonephritis and other tissue injury in SLE.[1]


  1. Complement gene expression in hepatic and extrahepatic tissues of NZB and NZB x W (F1) mouse strains. Passwell, J.H., Schreiner, G.F., Wetsel, R.A., Colten, H.R. Immunology (1990) [Pubmed]
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