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MeSH Review

Immune Complex Diseases

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Disease relevance of Immune Complex Diseases


High impact information on Immune Complex Diseases

  • This study reports quantitative information on the concentration of complement receptor for C3b and C4b (CR1) on erythrocytes from normal individuals and patients with immune complex disease [6].
  • In conclusion, anti-C1q autoantibodies deposit in glomeruli together with C1q but induce overt renal disease only in the context of glomerular immune complex disease [7].
  • Guinea pigs with inherited deficiencies of complement components C2 or C4 have characteristics of immune complex disease [8].
  • Two complement-dependent assays for circulating immune complexes, the C1q-binding assay and the conglutinin binding, were used to study patients with suspected immune-complex disease [9].
  • However, the importance of biliary IgA antibodies is largely unclarified, and man lacks the capacity for effective clearance of IgA-antigen complexes via the secretory component-mediated transhepatocellular pathway; whether this deficit contributes to the propensity for man to develop IgA immune complex diseases should be clarified [10].

Chemical compound and disease context of Immune Complex Diseases


Biological context of Immune Complex Diseases


Anatomical context of Immune Complex Diseases


Gene context of Immune Complex Diseases


  1. Interleukin 6 production in experimental cerebral malaria: modulation by anticytokine antibodies and possible role in hypergammaglobulinemia. Grau, G.E., Frei, K., Piguet, P.F., Fontana, A., Heremans, H., Billiau, A., Vassalli, P., Lambert, P.H. J. Exp. Med. (1990) [Pubmed]
  2. Effectiveness of nafamostat mesilate on glomerulonephritis in immune-complex diseases. Miyata, T., Fujita, Y., Inagi, R., Inoue, I., Sugiyama, S., Maeda, K. Lancet (1993) [Pubmed]
  3. Platelets, serotonin, migraine, and immune-complex disease. Parbtani, A., Cameron, J.S. Lancet (1978) [Pubmed]
  4. A new small molecule C5a receptor antagonist inhibits the reverse-passive Arthus reaction and endotoxic shock in rats. Strachan, A.J., Woodruff, T.M., Haaima, G., Fairlie, D.P., Taylor, S.M. J. Immunol. (2000) [Pubmed]
  5. Renal expression of monocyte chemoattractant protein-1 in lupus autoimmune mice. Zoja, C., Liu, X.H., Donadelli, R., Abbate, M., Testa, D., Corna, D., Taraboletti, G., Vecchi, A., Dong, Q.G., Rollins, B.J., Bertani, T., Remuzzi, G. J. Am. Soc. Nephrol. (1997) [Pubmed]
  6. Complement receptor (CR1) deficiency in erythrocytes from patients with systemic lupus erythematosus. Iida, K., Mornaghi, R., Nussenzweig, V. J. Exp. Med. (1982) [Pubmed]
  7. Anti-C1q autoantibodies deposit in glomeruli but are only pathogenic in combination with glomerular C1q-containing immune complexes. Trouw, L.A., Groeneveld, T.W., Seelen, M.A., Duijs, J.M., Bajema, I.M., Prins, F.A., Kishore, U., Salant, D.J., Verbeek, J.S., van Kooten, C., Daha, M.R. J. Clin. Invest. (2004) [Pubmed]
  8. Guinea pigs with inherited deficiencies of complement components C2 or C4 have characteristics of immune complex disease. Böttger, E.C., Hoffmann, T., Hadding, U., Bitter-Suermann, D. J. Clin. Invest. (1986) [Pubmed]
  9. Value of immune-complex assays in diagnosis and management. Pussell, B.A., Lockwood, C.M., Scott, D.M., Pinching, A.J., Peters, D.K. Lancet (1978) [Pubmed]
  10. The liver and IgA: immunological, cell biological and clinical implications. Brown, W.R., Kloppel, T.M. Hepatology (1989) [Pubmed]
  11. Human mononuclear phagocytes express adenosine A1 receptors. A novel mechanism for differential regulation of Fc gamma receptor function. Salmon, J.E., Brogle, N., Brownlie, C., Edberg, J.C., Kimberly, R.P., Chen, B.X., Erlanger, B.F. J. Immunol. (1993) [Pubmed]
  12. Accumulation of immune complexes in glomerular disease is independent of locally synthesized c3. Sheerin, N.S., Abe, K., Risley, P., Sacks, S.H. J. Am. Soc. Nephrol. (2006) [Pubmed]
  13. Cimetidine-induced cutaneous vasculitis. Mitchell, G.G., Magnusson, A.R., Weiler, J.M. Am. J. Med. (1983) [Pubmed]
  14. Effect of plasma exchange on circulating immune complexes and antibody formation in patients treated with cyclophosphamide and prednisone. Rossen, R.D., Hersh, E.M., Sharp, J.T., McCredie, K.B., Gyorkey, F., Suki, W.N., Eknoyan, G., Reisberg, M.A. Am. J. Med. (1977) [Pubmed]
  15. Ceftazidime treatment of chronic Pseudomonas aeruginosa respiratory tract infection in cystic fibrosis. Permin, H., Koch, C., Høiby, N., Christensen, H.O., Møller, A.F., Møller, S. J. Antimicrob. Chemother. (1983) [Pubmed]
  16. Sulfadiazine-induced allergy in six Doberman pinschers. Giger, U., Werner, L.L., Millichamp, N.J., Gorman, N.T. J. Am. Vet. Med. Assoc. (1985) [Pubmed]
  17. The role of altered vascular permeability in recurrent uveitis. Limaye, S.R., Rao, N.A., Phillips, T.M., Marak, G.E. International ophthalmology. (1981) [Pubmed]
  18. Biochemical characterization of the fibronectin binding sites for IgG. Rostagno, A.A., Frangione, B., Gold, L.I. J. Immunol. (1989) [Pubmed]
  19. Lymphocytes induce monocyte chemoattractant protein-1 production by renal cells after Fc gamma receptor cross-linking: role of IL-1beta. Rovin, B.H., Lu, L., Marsh, C.B. J. Leukoc. Biol. (2001) [Pubmed]
  20. Covert transport dysfunction in the choroid plexus as a possible cause of schizophrenia. Rudin, D.O. Schizophrenia bulletin. (1979) [Pubmed]
  21. Immunopathology of interstitial cystitis. Said, J.W., Van de Velde, R., Gillespie, L. Mod. Pathol. (1989) [Pubmed]
  22. Clustering of neutrophil leucocytes in serum: possible role of C1q-containing immune complexes. Sturfelt, G., Jonsson, H., Hellmer, G., Sjöholm, A.G. Clin. Exp. Immunol. (1993) [Pubmed]
  23. Comparative analysis of the disease-associated complement C4 gene from the HLA-A1, B8, DR3 haplotype. Ulgiati, D., Abraham, L.J. Exp. Clin. Immunogenet. (1996) [Pubmed]
  24. Cytokines in leprosy, I. Serum cytokine profile in leprosy. Moubasher, A.D., Kamel, N.A., Zedan, H., Raheem, D.D. International journal of dermatology. (1998) [Pubmed]
  25. Macrophages induce the inflammatory response in the pulmonary Arthus reaction through G alpha i2 activation that controls C5aR and Fc receptor cooperation. Skokowa, J., Ali, S.R., Felda, O., Kumar, V., Konrad, S., Shushakova, N., Schmidt, R.E., Piekorz, R.P., Nürnberg, B., Spicher, K., Birnbaumer, L., Zwirner, J., Claassens, J.W., Verbeek, J.S., van Rooijen, N., Köhl, J., Gessner, J.E. J. Immunol. (2005) [Pubmed]
  26. Acquired C1 esterase-inhibitor deficiency: case report with emphasis on complement and kallikrein activation during two patterns of clinical manifestations. Hentges, F., Humbel, R., Dicato, M., Hemmer, R., Kuntziger, H. J. Allergy Clin. Immunol. (1986) [Pubmed]
  27. Pre-neutralization of C5a-mediated effects by the monoclonal antibody 137-26 reacting with the C5a moiety of native C5 without preventing C5 cleavage. Fung, M., Lu, M., Fure, H., Sun, W., Sun, C., Shi, N.Y., Dou, Y., Su, J., Swanson, X., Mollnes, T.E. Clin. Exp. Immunol. (2003) [Pubmed]
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