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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Spectral assignment and cytotoxicity of 22-hydroxytingenone from Glyptopetalum sclerocarpum.

22-Hydroxytingenone was reisolated from a new source, Glyptopetalum sclerocarpum M. Laws and, for the first time, its unambiguous 13C-NMR assignments were accomplished through the use of APT, HETCOR, and selective INEPT spectroscopy. Intense, but nonspecific cytotoxic activity was observed when this substance was evaluated with a battery of cell lines comprised of the P-388 lymphocytic leukemia, KB carcinoma of the nasopharynx, and a number of human cancer cell types, i.e. HT-1080 fibrosarcoma, LU-1 lung cancer, COL-2 colon cancer, MEL-2 melanoma, and BC-1 breast cancer.[1]


  1. Spectral assignment and cytotoxicity of 22-hydroxytingenone from Glyptopetalum sclerocarpum. Bavovada, R., Blaskó, G., Shieh, H.L., Pezzuto, J.M., Cordell, G.A. Planta Med. (1990) [Pubmed]
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