Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Diagnostic Performances of Hepatitis C Virus-NS4 Antigen in Patients with Different Liver Pathologies.

BACKGROUND AND AIMS: Hepatitis C virus (HCV) has emerged as the major pathogen of liver disease worldwide. The aim of this study was to quantitate and evaluate the performance of HCV-NS4 antigen as an alternative approach for confirmation of viremia. METHODS: Detection of HCV-NS4 was assessed in 883 patients with chronic hepatitis C. Areas under the ROC curves (AUC) were used to assess and compare diagnostic accuracy of ELISA for HCV-NS4 with quantitative HCV-RNA as a gold standard. RESULTS: HCV-NS4 was identified at 27 kDa using Western blot. AUC for HCV-NS4 detection was 0.95 for all patients with different liver pathologies: 0.93 for liver fibrosis (LF), 0.95 for liver cirrhosis (LC) and 0.98 for hepatocellular carcinoma (HCC). The mean ± SD (μg/mL) of HCV-NS4 in LF was 94.2 ± 55.6; in LC was 99.3 ± 64.8 and in HCC was 124.9 ± 70.3. CONCLUSIONS: HCV-NS4 antigen detection using ELISA is a reliable test in the confirmation of HCV infection.[1]

References

Diagnostic Performances of Hepatitis C Virus-NS4 Antigen in Patients with Different Liver Pathologies. Attallah, A.M., Omran, M.M., Nasif, W.A., Ghaly, M.F., El-Shanshoury, A.R., Abdalla, M.S., Sharada, H.M., Farid, K., El-Shony, W., Moussa, E.S., El-Domany, E.B., Nour, E., Eldosoky, I. Arch. Med. Res. (2012) [Pubmed]

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