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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 

Superior vena cava syndrome caused by systemic lupus erythematosus in a patient with longstanding rheumatoid arthritis.

Superior vena cava syndrome is mostly related to a malignant process, but many different benign causes have also been described. We report a patient with longstanding classic rheumatoid arthritis ( RA), who developed a superior vena cava syndrome due to mediastinal lymphadenopathy. At that time she also fulfilled the ARA criteria for systemic lupus erythematosus ( SLE). Histological examination of a lymph node biopsy revealed necrosis, hematoxylin bodies and LE cells, while a great amount of amorphous proteinaceous material was seen positive with immunofluorescence for IgG, IgM and complement (C3 and Clq). A diagnosis of superior vena cava syndrome due to mediastinal lymphadenopathy in a patient with SLE which had evolved from longstanding RA was established.[1]

References

  1. Superior vena cava syndrome caused by systemic lupus erythematosus in a patient with longstanding rheumatoid arthritis. van den Brink, H., Vroom, T.M., van de Laar, M.A., van Soesbergen, R.M., van der Korst, J.K. J. Rheumatol. (1990) [Pubmed]
 
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