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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Role of endothelium-derived nitric oxide in the regulation of blood pressure.

The role of endothelium-derived nitric oxide in the regulation of blood pressure in the anesthetized rabbit was studied with N omega-monomethyl-L-arginine (L-NMMA), a specific inhibitor of its formation from L-arginine. L-NMMA (3-100, but not its D-enantiomer, induced a dose-dependent long-lasting (15-90 min) increase in mean systemic arterial blood pressure. L-NMMA (100 also inhibited significantly the hypotensive action of acetylcholine, without affecting that of glyceryl trinitrate. Both these actions of L-NMMA were reversed by L-arginine (300, but not by D-arginine (300, indomethacin (1, prazosin (0.3, or by vagotomy. The effects of L-NMMA in vivo were associated with a significant inhibition of the release of nitric oxide from perfused aortic segments ex vivo. This inhibition was reversed by infusing L-arginine through the aortic segments. These results indicate that nitric oxide formation from L-arginine by the vascular endothelium plays a role in the regulation of blood pressure and in the hypotensive actions of acetylcholine.[1]


  1. Role of endothelium-derived nitric oxide in the regulation of blood pressure. Rees, D.D., Palmer, R.M., Moncada, S. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
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