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Chemical Compound Review

N(G)-Methylarginine     2-amino-5-[(N'- methylcarbamimidoyl)amino]p...

Synonyms: Tilarginine, Methylarginine, CHEMBL312870, L-Monomethylarginine, N(G)-Monomethylarginine, ...
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Disease relevance of omega-N-METHYLARGININE

  • Inhibition of EDRF synthesis by treatment with NG-monomethyl-L-arginine (10(-4) M) eliminated this difference, increasing the tension in the rings from the controls (P less than 0.01) but not in those from the patients with chronic lung disease [1].
  • The role of nitric oxide in the pathogenesis of spontaneous murine autoimmune disease: increased nitric oxide production and nitric oxide synthase expression in MRL-lpr/lpr mice, and reduction of spontaneous glomerulonephritis and arthritis by orally administered NG-monomethyl-L-arginine [2].
  • This neurogenic relaxation was reduced or prevented by L-NMMA, oxyhemoglobin, methylene blue, and hypoxia [3].
  • Furthermore, administration of substrate analogues such as L-NMMA may favorably alter the toxicity associated with these immunomodulators and result in a higher maximum tolerated dose, with subsequent improvement in the antitumor activity [4].
  • In conclusion, ICV administration of L-NMMA causes hyperglycemia via the induction of defects in insulin secretion and insulin action, thus recapitulating abnormalities observed in type 2 diabetes [5].

Psychiatry related information on omega-N-METHYLARGININE


High impact information on omega-N-METHYLARGININE


Chemical compound and disease context of omega-N-METHYLARGININE


Biological context of omega-N-METHYLARGININE


Anatomical context of omega-N-METHYLARGININE


Associations of omega-N-METHYLARGININE with other chemical compounds

  • To determine whether an endogenous nitric-oxide (NO)-signaling pathway within ventricular myocytes was responsible for their decreased responsiveness to isoproterenol, the L-arginine analogue L-NMMA was added to the preincubation medium [27].
  • In another group (n = 6), intraarterially infused L-NMMA (4 mumol/min for 5 min) increased baseline FVR without systemic effects, and inhibited acetylcholine-induced vasodilation (P < 0.01) [28].
  • Indomethacin or removal of endothelium abolished this decreased response, whereas L-NMMA had no effect [29].
  • Addition of the competitive NO synthase inhibitor L-NMMA to the culture medium prevented both the increased nitrite production and the cytotoxicity observed after cytokine treatment in both the isolated myocyte and the coculture experiments [30].
  • N-monomethyl-L-arginine (L-NMMA), a specific inhibitor of NO synthase, was administered directly into the femoral artery of normal subjects at a dose of 16 mg/min and leg blood flow (LBF) was measured during an infusion of saline (NS) or during a euglycemic hyperinsulinemic clamp (HIC) designed to approximately double LBF [31].

Gene context of omega-N-METHYLARGININE


Analytical, diagnostic and therapeutic context of omega-N-METHYLARGININE


  1. Impairment of endothelium-dependent pulmonary-artery relaxation in chronic obstructive lung disease. Dinh-Xuan, A.T., Higenbottam, T.W., Clelland, C.A., Pepke-Zaba, J., Cremona, G., Butt, A.Y., Large, S.R., Wells, F.C., Wallwork, J. N. Engl. J. Med. (1991) [Pubmed]
  2. The role of nitric oxide in the pathogenesis of spontaneous murine autoimmune disease: increased nitric oxide production and nitric oxide synthase expression in MRL-lpr/lpr mice, and reduction of spontaneous glomerulonephritis and arthritis by orally administered NG-monomethyl-L-arginine. Weinberg, J.B., Granger, D.L., Pisetsky, D.S., Seldin, M.F., Misukonis, M.A., Mason, S.N., Pippen, A.M., Ruiz, P., Wood, E.R., Gilkeson, G.S. J. Exp. Med. (1994) [Pubmed]
  3. A nitric oxide-like factor mediates nonadrenergic-noncholinergic neurogenic relaxation of penile corpus cavernosum smooth muscle. Kim, N., Azadzoi, K.M., Goldstein, I., Saenz de Tejada, I. J. Clin. Invest. (1991) [Pubmed]
  4. Endothelial cell production of nitrogen oxides in response to interferon gamma in combination with tumor necrosis factor, interleukin-1, or endotoxin. Kilbourn, R.G., Belloni, P. J. Natl. Cancer Inst. (1990) [Pubmed]
  5. Central nervous system nitric oxide synthase activity regulates insulin secretion and insulin action. Shankar, R., Zhu, J.S., Ladd, B., Henry, D., Shen, H.Q., Baron, A.D. J. Clin. Invest. (1998) [Pubmed]
  6. Evidence that nitric oxide mechanisms regulate small intestinal motility in humans. Russo, A., Fraser, R., Adachi, K., Horowitz, M., Boeckxstaens, G. Gut (1999) [Pubmed]
  7. Role of nitric oxide in gastric motor and sensory functions in healthy subjects. Kuiken, S.D., Vergeer, M., Heisterkamp, S.H., Tytgat, G.N., Boeckxstaens, G.E. Gut (2002) [Pubmed]
  8. Nitric oxide synthase inhibition reduces wakefulness. Dzoljic, M.R., De Vries, R. Neuropharmacology (1994) [Pubmed]
  9. Suppression of herpes simplex virus type 1 (HSV-1)-induced pneumonia in mice by inhibition of inducible nitric oxide synthase (iNOS, NOS2). Adler, H., Beland, J.L., Del-Pan, N.C., Kobzik, L., Brewer, J.P., Martin, T.R., Rimm, I.J. J. Exp. Med. (1997) [Pubmed]
  10. Spontaneously increased production of nitric oxide and aberrant expression of the inducible nitric oxide synthase in vivo in the transforming growth factor beta 1 null mouse. Vodovotz, Y., Geiser, A.G., Chesler, L., Letterio, J.J., Campbell, A., Lucia, M.S., Sporn, M.B., Roberts, A.B. J. Exp. Med. (1996) [Pubmed]
  11. Tumor necrosis factor alpha activates soluble guanylate cyclase in bovine glomerular mesangial cells via an L-arginine-dependent mechanism. Marsden, P.A., Ballermann, B.J. J. Exp. Med. (1990) [Pubmed]
  12. Antithrombotic activity of TNF-alpha. Cambien, B., Bergmeier, W., Saffaripour, S., Mitchell, H.A., Wagner, D.D. J. Clin. Invest. (2003) [Pubmed]
  13. Effects of inhaled nitric oxide on regional blood flow are consistent with intravascular nitric oxide delivery. Cannon, R.O., Schechter, A.N., Panza, J.A., Ognibene, F.P., Pease-Fye, M.E., Waclawiw, M.A., Shelhamer, J.H., Gladwin, M.T. J. Clin. Invest. (2001) [Pubmed]
  14. Interleukin 1 beta induces the formation of nitric oxide by beta-cells purified from rodent islets of Langerhans. Evidence for the beta-cell as a source and site of action of nitric oxide. Corbett, J.A., Wang, J.L., Sweetland, M.A., Lancaster, J.R., McDaniel, M.L. J. Clin. Invest. (1992) [Pubmed]
  15. Increased nitric oxide synthesis in ulcerative colitis. Middleton, S.J., Shorthouse, M., Hunter, J.O. Lancet (1993) [Pubmed]
  16. Modulation of the hyperdynamic circulation of cirrhotic rats by nitric oxide inhibition. Pizcueta, P., Piqué, J.M., Fernández, M., Bosch, J., Rodés, J., Whittle, B.J., Moncada, S. Gastroenterology (1992) [Pubmed]
  17. Coronary vascular nitric oxide activity in hypertension and hypercholesterolemia. Comparison of acetylcholine and substance P. Quyyumi, A.A., Mulcahy, D., Andrews, N.P., Husain, S., Panza, J.A., Cannon, R.O. Circulation (1997) [Pubmed]
  18. Nitric oxide release accounts for insulin's vascular effects in humans. Scherrer, U., Randin, D., Vollenweider, P., Vollenweider, L., Nicod, P. J. Clin. Invest. (1994) [Pubmed]
  19. Roles of endothelin-1 and nitric oxide in the mechanism for ethanol-induced vasoconstriction in rat liver. Oshita, M., Takei, Y., Kawano, S., Yoshihara, H., Hijioka, T., Fukui, H., Goto, M., Masuda, E., Nishimura, Y., Fusamoto, H. J. Clin. Invest. (1993) [Pubmed]
  20. Nitric oxide suppression of human hematopoiesis in vitro. Contribution to inhibitory action of interferon-gamma and tumor necrosis factor-alpha. Maciejewski, J.P., Selleri, C., Sato, T., Cho, H.J., Keefer, L.K., Nathan, C.F., Young, N.S. J. Clin. Invest. (1995) [Pubmed]
  21. Adaptation to increased dietary salt intake in the rat. Role of endogenous nitric oxide. Shultz, P.J., Tolins, J.P. J. Clin. Invest. (1993) [Pubmed]
  22. Activated macrophages depress the contractility of rabbit carotids via an L-arginine/nitric oxide-dependent effector mechanism. Connection with amplified cytokine release. Bernard, C., Szekely, B., Philip, I., Wollman, E., Payen, D., Tedgui, A. J. Clin. Invest. (1992) [Pubmed]
  23. Effects of inhibition of nitric oxide formation on basal vasomotion and endothelium-dependent responses of the coronary arteries in awake dogs. Chu, A., Chambers, D.E., Lin, C.C., Kuehl, W.D., Palmer, R.M., Moncada, S., Cobb, F.R. J. Clin. Invest. (1991) [Pubmed]
  24. NG-monomethyl-L-arginine inhibits the blood flow but not the insulin-like response of forearm muscle to IGF- I: possible role of nitric oxide in muscle protein synthesis. Fryburg, D.A. J. Clin. Invest. (1996) [Pubmed]
  25. Nitric oxide mediates angiogenesis in vivo and endothelial cell growth and migration in vitro promoted by substance P. Ziche, M., Morbidelli, L., Masini, E., Amerini, S., Granger, H.J., Maggi, C.A., Geppetti, P., Ledda, F. J. Clin. Invest. (1994) [Pubmed]
  26. Inducible production of nitric oxide in osteoblast-like cells and in fetal mouse bone explants is associated with suppression of osteoclastic bone resorption. Löwik, C.W., Nibbering, P.H., van de Ruit, M., Papapoulos, S.E. J. Clin. Invest. (1994) [Pubmed]
  27. Abnormal contractile function due to induction of nitric oxide synthesis in rat cardiac myocytes follows exposure to activated macrophage-conditioned medium. Balligand, J.L., Ungureanu, D., Kelly, R.A., Kobzik, L., Pimental, D., Michel, T., Smith, T.W. J. Clin. Invest. (1993) [Pubmed]
  28. Vasodilatory effect of arginine vasopressin is mediated by nitric oxide in human forearm vessels. Tagawa, T., Imaizumi, T., Endo, T., Shiramoto, M., Hirooka, Y., Ando, S., Takeshita, A. J. Clin. Invest. (1993) [Pubmed]
  29. Endothelium dependency of contractile activity differs in infant and adult vertebral arteries. Charpie, J.R., Schreur, K.D., Papadopoulos, S.M., Webb, R.C. J. Clin. Invest. (1994) [Pubmed]
  30. The lethal effects of cytokine-induced nitric oxide on cardiac myocytes are blocked by nitric oxide synthase antagonism or transforming growth factor beta. Pinsky, D.J., Cai, B., Yang, X., Rodriguez, C., Sciacca, R.R., Cannon, P.J. J. Clin. Invest. (1995) [Pubmed]
  31. Insulin-mediated skeletal muscle vasodilation is nitric oxide dependent. A novel action of insulin to increase nitric oxide release. Steinberg, H.O., Brechtel, G., Johnson, A., Fineberg, N., Baron, A.D. J. Clin. Invest. (1994) [Pubmed]
  32. Endothelin (ET)-3 stimulates cyclic guanosine 3',5'-monophosphate production via ETB receptor by producing nitric oxide in isolated rat glomerulus, and in cultured rat mesangial cells. Owada, A., Tomita, K., Terada, Y., Sakamoto, H., Nonoguchi, H., Marumo, F. J. Clin. Invest. (1994) [Pubmed]
  33. Nitric oxide regulates vascular cell adhesion molecule 1 gene expression and redox-sensitive transcriptional events in human vascular endothelial cells. Khan, B.V., Harrison, D.G., Olbrych, M.T., Alexander, R.W., Medford, R.M. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  34. Inhibition of cytochromes P4501A by nitric oxide. Stadler, J., Trockfeld, J., Schmalix, W.A., Brill, T., Siewert, J.R., Greim, H., Doehmer, J. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  35. Rate of vasoconstrictor prostanoids released by endothelial cells depends on cyclooxygenase-2 expression and prostaglandin I synthase activity. Camacho, M., López-Belmonte, J., Vila, L. Circ. Res. (1998) [Pubmed]
  36. Role of nitric oxide in the anti-tumoral effect of retinoic acid and 1,25-dihydroxyvitamin D3 on human promonocytic leukemic cells. Dugas, N., Mossalayi, M.D., Calenda, A., Léotard, A., Bécherel, P., Mentz, F., Ouaaz, F., Arock, M., Debré, P., Dornand, J., Dugas, B. Blood (1996) [Pubmed]
  37. Effect of inhibition of nitric oxide synthase on chronic tension-type headache: a randomised crossover trial. Ashina, M., Lassen, L.H., Bendtsen, L., Jensen, R., Olesen, J. Lancet (1999) [Pubmed]
  38. Endotoxin-stimulated nitric oxide production increases injury and reduces rat liver chemiluminescence during reperfusion. Ma, T.T., Ischiropoulos, H., Brass, C.A. Gastroenterology (1995) [Pubmed]
  39. Inhibition of nitric oxide synthesis in septic shock: how much is beneficial? Nava, E., Palmer, R.M., Moncada, S. Lancet (1991) [Pubmed]
  40. Effects of acute normovolemic anemia on gastric mucosal blood flow in rats: role of nitric oxide. Panés, J., Casadevall, M., Piqué, J.M., Bosch, J., Whittle, B.J., Terés, J. Gastroenterology (1992) [Pubmed]
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