Chemical Compound Review:
N(G)-Methylarginine 2-amino-5-[(N'- methylcarbamimidoyl)amino]p...
Synonyms:
Tilarginine, Methylarginine, CHEMBL312870, L-Monomethylarginine, N(G)-Monomethylarginine, ...
- Impairment of endothelium-dependent pulmonary-artery relaxation in chronic obstructive lung disease. Dinh-Xuan, A.T., Higenbottam, T.W., Clelland, C.A., Pepke-Zaba, J., Cremona, G., Butt, A.Y., Large, S.R., Wells, F.C., Wallwork, J. N. Engl. J. Med. (1991)
- The role of nitric oxide in the pathogenesis of spontaneous murine autoimmune disease: increased nitric oxide production and nitric oxide synthase expression in MRL-lpr/lpr mice, and reduction of spontaneous glomerulonephritis and arthritis by orally administered NG-monomethyl-L-arginine. Weinberg, J.B., Granger, D.L., Pisetsky, D.S., Seldin, M.F., Misukonis, M.A., Mason, S.N., Pippen, A.M., Ruiz, P., Wood, E.R., Gilkeson, G.S. J. Exp. Med. (1994)
- A nitric oxide-like factor mediates nonadrenergic-noncholinergic neurogenic relaxation of penile corpus cavernosum smooth muscle. Kim, N., Azadzoi, K.M., Goldstein, I., Saenz de Tejada, I. J. Clin. Invest. (1991)
- Endothelial cell production of nitrogen oxides in response to interferon gamma in combination with tumor necrosis factor, interleukin-1, or endotoxin. Kilbourn, R.G., Belloni, P. J. Natl. Cancer Inst. (1990)
- Central nervous system nitric oxide synthase activity regulates insulin secretion and insulin action. Shankar, R., Zhu, J.S., Ladd, B., Henry, D., Shen, H.Q., Baron, A.D. J. Clin. Invest. (1998)
- Evidence that nitric oxide mechanisms regulate small intestinal motility in humans. Russo, A., Fraser, R., Adachi, K., Horowitz, M., Boeckxstaens, G. Gut (1999)
- Role of nitric oxide in gastric motor and sensory functions in healthy subjects. Kuiken, S.D., Vergeer, M., Heisterkamp, S.H., Tytgat, G.N., Boeckxstaens, G.E. Gut (2002)
- Nitric oxide synthase inhibition reduces wakefulness. Dzoljic, M.R., De Vries, R. Neuropharmacology (1994)
- Suppression of herpes simplex virus type 1 (HSV-1)-induced pneumonia in mice by inhibition of inducible nitric oxide synthase (iNOS, NOS2). Adler, H., Beland, J.L., Del-Pan, N.C., Kobzik, L., Brewer, J.P., Martin, T.R., Rimm, I.J. J. Exp. Med. (1997)
- Spontaneously increased production of nitric oxide and aberrant expression of the inducible nitric oxide synthase in vivo in the transforming growth factor beta 1 null mouse. Vodovotz, Y., Geiser, A.G., Chesler, L., Letterio, J.J., Campbell, A., Lucia, M.S., Sporn, M.B., Roberts, A.B. J. Exp. Med. (1996)
- Tumor necrosis factor alpha activates soluble guanylate cyclase in bovine glomerular mesangial cells via an L-arginine-dependent mechanism. Marsden, P.A., Ballermann, B.J. J. Exp. Med. (1990)
- Antithrombotic activity of TNF-alpha. Cambien, B., Bergmeier, W., Saffaripour, S., Mitchell, H.A., Wagner, D.D. J. Clin. Invest. (2003)
- Effects of inhaled nitric oxide on regional blood flow are consistent with intravascular nitric oxide delivery. Cannon, R.O., Schechter, A.N., Panza, J.A., Ognibene, F.P., Pease-Fye, M.E., Waclawiw, M.A., Shelhamer, J.H., Gladwin, M.T. J. Clin. Invest. (2001)
- Interleukin 1 beta induces the formation of nitric oxide by beta-cells purified from rodent islets of Langerhans. Evidence for the beta-cell as a source and site of action of nitric oxide. Corbett, J.A., Wang, J.L., Sweetland, M.A., Lancaster, J.R., McDaniel, M.L. J. Clin. Invest. (1992)
- Increased nitric oxide synthesis in ulcerative colitis. Middleton, S.J., Shorthouse, M., Hunter, J.O. Lancet (1993)
- Modulation of the hyperdynamic circulation of cirrhotic rats by nitric oxide inhibition. Pizcueta, P., Piqué, J.M., Fernández, M., Bosch, J., Rodés, J., Whittle, B.J., Moncada, S. Gastroenterology (1992)
- Coronary vascular nitric oxide activity in hypertension and hypercholesterolemia. Comparison of acetylcholine and substance P. Quyyumi, A.A., Mulcahy, D., Andrews, N.P., Husain, S., Panza, J.A., Cannon, R.O. Circulation (1997)
- Nitric oxide release accounts for insulin's vascular effects in humans. Scherrer, U., Randin, D., Vollenweider, P., Vollenweider, L., Nicod, P. J. Clin. Invest. (1994)
- Roles of endothelin-1 and nitric oxide in the mechanism for ethanol-induced vasoconstriction in rat liver. Oshita, M., Takei, Y., Kawano, S., Yoshihara, H., Hijioka, T., Fukui, H., Goto, M., Masuda, E., Nishimura, Y., Fusamoto, H. J. Clin. Invest. (1993)
- Nitric oxide suppression of human hematopoiesis in vitro. Contribution to inhibitory action of interferon-gamma and tumor necrosis factor-alpha. Maciejewski, J.P., Selleri, C., Sato, T., Cho, H.J., Keefer, L.K., Nathan, C.F., Young, N.S. J. Clin. Invest. (1995)
- Adaptation to increased dietary salt intake in the rat. Role of endogenous nitric oxide. Shultz, P.J., Tolins, J.P. J. Clin. Invest. (1993)
- Activated macrophages depress the contractility of rabbit carotids via an L-arginine/nitric oxide-dependent effector mechanism. Connection with amplified cytokine release. Bernard, C., Szekely, B., Philip, I., Wollman, E., Payen, D., Tedgui, A. J. Clin. Invest. (1992)
- Effects of inhibition of nitric oxide formation on basal vasomotion and endothelium-dependent responses of the coronary arteries in awake dogs. Chu, A., Chambers, D.E., Lin, C.C., Kuehl, W.D., Palmer, R.M., Moncada, S., Cobb, F.R. J. Clin. Invest. (1991)
- NG-monomethyl-L-arginine inhibits the blood flow but not the insulin-like response of forearm muscle to IGF- I: possible role of nitric oxide in muscle protein synthesis. Fryburg, D.A. J. Clin. Invest. (1996)
- Nitric oxide mediates angiogenesis in vivo and endothelial cell growth and migration in vitro promoted by substance P. Ziche, M., Morbidelli, L., Masini, E., Amerini, S., Granger, H.J., Maggi, C.A., Geppetti, P., Ledda, F. J. Clin. Invest. (1994)
- Inducible production of nitric oxide in osteoblast-like cells and in fetal mouse bone explants is associated with suppression of osteoclastic bone resorption. Löwik, C.W., Nibbering, P.H., van de Ruit, M., Papapoulos, S.E. J. Clin. Invest. (1994)
- Abnormal contractile function due to induction of nitric oxide synthesis in rat cardiac myocytes follows exposure to activated macrophage-conditioned medium. Balligand, J.L., Ungureanu, D., Kelly, R.A., Kobzik, L., Pimental, D., Michel, T., Smith, T.W. J. Clin. Invest. (1993)
- Vasodilatory effect of arginine vasopressin is mediated by nitric oxide in human forearm vessels. Tagawa, T., Imaizumi, T., Endo, T., Shiramoto, M., Hirooka, Y., Ando, S., Takeshita, A. J. Clin. Invest. (1993)
- Endothelium dependency of contractile activity differs in infant and adult vertebral arteries. Charpie, J.R., Schreur, K.D., Papadopoulos, S.M., Webb, R.C. J. Clin. Invest. (1994)
- The lethal effects of cytokine-induced nitric oxide on cardiac myocytes are blocked by nitric oxide synthase antagonism or transforming growth factor beta. Pinsky, D.J., Cai, B., Yang, X., Rodriguez, C., Sciacca, R.R., Cannon, P.J. J. Clin. Invest. (1995)
- Insulin-mediated skeletal muscle vasodilation is nitric oxide dependent. A novel action of insulin to increase nitric oxide release. Steinberg, H.O., Brechtel, G., Johnson, A., Fineberg, N., Baron, A.D. J. Clin. Invest. (1994)
- Endothelin (ET)-3 stimulates cyclic guanosine 3',5'-monophosphate production via ETB receptor by producing nitric oxide in isolated rat glomerulus, and in cultured rat mesangial cells. Owada, A., Tomita, K., Terada, Y., Sakamoto, H., Nonoguchi, H., Marumo, F. J. Clin. Invest. (1994)
- Nitric oxide regulates vascular cell adhesion molecule 1 gene expression and redox-sensitive transcriptional events in human vascular endothelial cells. Khan, B.V., Harrison, D.G., Olbrych, M.T., Alexander, R.W., Medford, R.M. Proc. Natl. Acad. Sci. U.S.A. (1996)
- Inhibition of cytochromes P4501A by nitric oxide. Stadler, J., Trockfeld, J., Schmalix, W.A., Brill, T., Siewert, J.R., Greim, H., Doehmer, J. Proc. Natl. Acad. Sci. U.S.A. (1994)
- Rate of vasoconstrictor prostanoids released by endothelial cells depends on cyclooxygenase-2 expression and prostaglandin I synthase activity. Camacho, M., López-Belmonte, J., Vila, L. Circ. Res. (1998)
- Role of nitric oxide in the anti-tumoral effect of retinoic acid and 1,25-dihydroxyvitamin D3 on human promonocytic leukemic cells. Dugas, N., Mossalayi, M.D., Calenda, A., Léotard, A., Bécherel, P., Mentz, F., Ouaaz, F., Arock, M., Debré, P., Dornand, J., Dugas, B. Blood (1996)
- Effect of inhibition of nitric oxide synthase on chronic tension-type headache: a randomised crossover trial. Ashina, M., Lassen, L.H., Bendtsen, L., Jensen, R., Olesen, J. Lancet (1999)
- Endotoxin-stimulated nitric oxide production increases injury and reduces rat liver chemiluminescence during reperfusion. Ma, T.T., Ischiropoulos, H., Brass, C.A. Gastroenterology (1995)
- Inhibition of nitric oxide synthesis in septic shock: how much is beneficial? Nava, E., Palmer, R.M., Moncada, S. Lancet (1991)
- Effects of acute normovolemic anemia on gastric mucosal blood flow in rats: role of nitric oxide. Panés, J., Casadevall, M., Piqué, J.M., Bosch, J., Whittle, B.J., Terés, J. Gastroenterology (1992)