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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Chromosomal localization and expression of CBS1, a translational activator of cytochrome b in yeast.

Translation of mitochondrial cytochrome b RNA in yeast requires the product of the nuclear gene CBS1, a 27.5 kDa soluble mitochondrial protein. In this paper we show that the CBS1 gene is located on chromosome IV immediately adjacent to COX9, the gene coding for cytochrome c oxidase subunit VIIa. CBS1 is transcribed as a very low abundant 900 b RNA. Transcription starts at a single position 101 bp upstream of the CBS1 initiation codon. At positions -39 to -27 of its leader sequence it contains a small open reading frame of 4 codons. By monitoring the beta-galactosidase activity of a CBS1/lacZ fusion construct we show that expression of CBS1 is subjected to regulation by oxygen and by glucose: the beta-galactosidase activity is elevated threefold in glycerol or galactose grown cells compared to that in glucose grown cells. A further threefold reduction of the activity is observed in anaerobically grown cells. In accordance with this result is the observation that the steady-state level of CBS1 mRNA of anaerobically grown cells is ninefold lower than that of aerobically cultured cells.[1]


  1. Chromosomal localization and expression of CBS1, a translational activator of cytochrome b in yeast. Forsbach, V., Pillar, T., Gottenöf, T., Rödel, G. Mol. Gen. Genet. (1989) [Pubmed]
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