tctex-1: a candidate gene family for a mouse t complex sterility locus.
The t complex of the mouse has an important role in male germ cell development and function. Multiple mutations in the t complex interact to alter profoundly the transmission ratio of t complex-bearing sperm or to cause complete sterility or semisterility. We have isolated a multigene family, tctex-1, by screening a testicular cell cDNA library with two reciprocally subtracted testicular cDNA probes. The tctex-1 gene family produces an abundant, virtually germ cell-specific transcript that is 8-fold overexpressed in t homozygotes. The aberrant expression of tctex-1 is solely dependent on the t haplotype genes and occurs only in germ cells. The chromosomal location and pattern of expression of tctex-1 make it a candidate for involvement in male sterility.[1]References
- tctex-1: a candidate gene family for a mouse t complex sterility locus. Lader, E., Ha, H.S., O'Neill, M., Artzt, K., Bennett, D. Cell (1989) [Pubmed]
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