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Gene Review

Dynlt1b  -  dynein light chain Tctex-type 1B

Mus musculus

Synonyms: AGS2, Activator of G-protein signaling 2, Dynein light chain Tctex-type 1, Dynlt1, T-complex testis-specific protein 1, ...
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Disease relevance of Dynlt1


High impact information on Dynlt1


Biological context of Dynlt1

  • The cytoplasmic dynein light chain Tctex1 is a candidate for one of the distorter products involved in the non-Mendelian transmission of mouse t haplotypes [4].
  • The data showed that Tctex-1 adopts a structure remarkably similar to that of the 8-kDa light chain of the motor complex (DLC8), although the two light chains share no amino acid sequence homology [5].
  • The Tctex-1 binding site on DIC was mapped to a 19-residue fragment immediately following the second alternative splicing site of DIC [5].
  • The Tctex1/Tctex2 class of dynein light chains. Dimerization, differential expression, and interaction with the LC8 protein family [6].
  • Combined with the recent identification of Tctex-1 (another distorter candidate) as a light chain of cytoplasmic dynein, these results lead to a biochemical model for how differential defects in spermiogenesis that result in the phenomenon of meiotic drive might be generated in wild-type vs t-bearing sperm [7].

Anatomical context of Dynlt1

  • Here, we demonstrate that Tctex1 is not only a cytoplasmic dynein component, but is also present both in mouse sperm and Chlamydomonas flagella [4].
  • The minus-ended microtubule motor cytoplasmic dynein contains a number of low molecular weight light chains including the 14-kDa Tctex-1 [5].
  • We find that Tctex-1 protein is present in sperm tails and oocytes and that it is present at equal levels in wild-type and t-haplotype testis [8].
  • Tctex-1 binding required the first 19 amino acids of Fyn and integrity of two lysine residues within this sequence that were previously shown to be important for Fyn interactions with the immunoreceptor tyrosine-based activation motifs (ITAMs) of lymphocyte Ag receptors [3].
  • Interestingly, four Tctex genes show differences in the amount of transcript between wild-type and t-mutant testes [9].

Associations of Dynlt1 with chemical compounds

  • We further demonstrated that Tctex-1 binds directly to the intermediate chain (DIC) of dynein [5].

Physical interactions of Dynlt1

  • We utilized yeast two-hybrid cloning to identify the product of the tctex-1 gene as a protein that specifically interacts with Fyn, but not with other Src family kinases [3].

Regulatory relationships of Dynlt1


Other interactions of Dynlt1


Analytical, diagnostic and therapeutic context of Dynlt1

  • Gel filtration chromatography and native gel electrophoresis indicate that recombinant Chlamydomonas flagellar Tctex1 exists as a dimer in solution [6].
  • Immunofluorescence analysis was consistent with the tissue-specific distribution of these proteins and revealed that both rp3 and Tctex1 are present in multiple perinuclear punctate particles [11].


  1. A dynein light chain of sea urchin sperm flagella is a homolog of mouse Tctex 1, which is encoded by a gene of the t complex sterility locus. Kagami, O., Gotoh, M., Makino, Y., Mohri, H., Kamiya, R., Ogawa, K. Gene (1998) [Pubmed]
  2. tctex-1: a candidate gene family for a mouse t complex sterility locus. Lader, E., Ha, H.S., O'Neill, M., Artzt, K., Bennett, D. Cell (1989) [Pubmed]
  3. Interaction of p59fyn kinase with the dynein light chain, Tctex-1, and colocalization during cytokinesis. Campbell, K.S., Cooper, S., Dessing, M., Yates, S., Buder, A. J. Immunol. (1998) [Pubmed]
  4. Identification of the t complex-encoded cytoplasmic dynein light chain tctex1 in inner arm I1 supports the involvement of flagellar dyneins in meiotic drive. Harrison, A., Olds-Clarke, P., King, S.M. J. Cell Biol. (1998) [Pubmed]
  5. Structure of Tctex-1 and its interaction with cytoplasmic dynein intermediate chain. Mok, Y.K., Lo, K.W., Zhang, M. J. Biol. Chem. (2001) [Pubmed]
  6. The Tctex1/Tctex2 class of dynein light chains. Dimerization, differential expression, and interaction with the LC8 protein family. DiBella, L.M., Benashski, S.E., Tedford, H.W., Harrison, A., Patel-King, R.S., King, S.M. J. Biol. Chem. (2001) [Pubmed]
  7. A Chlamydomonas homologue of the putative murine t complex distorter Tctex-2 is an outer arm dynein light chain. Patel-King, R.S., Benashski, S.E., Harrison, A., King, S.M. J. Cell Biol. (1997) [Pubmed]
  8. Identification of a germ-cell-specific transcriptional repressor in the promoter of Tctex-1. O'Neill, M.J., Artzt, K. Development (1995) [Pubmed]
  9. Several testis-expressed genes in the mouse t-complex have expression differences between wild-type and t-mutant mice. Ha, H., Howard, C.A., Yeom, Y.I., Abe, K., Uehara, H., Artzt, K., Bennett, D. Dev. Genet. (1991) [Pubmed]
  10. Physical mapping of male fertility and meiotic drive quantitative trait loci in the mouse t complex using chromosome deficiencies. Planchart, A., You, Y., Schimenti, J.C. Genetics (2000) [Pubmed]
  11. Cytoplasmic dynein contains a family of differentially expressed light chains. King, S.M., Barbarese, E., Dillman, J.F., Benashski, S.E., Do, K.T., Patel-King, R.S., Pfister, K.K. Biochemistry (1998) [Pubmed]
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