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Gene Review

Tcp1  -  t-complex protein 1

Mus musculus

Synonyms: AI528772, CCT, CCT-alpha, Cct1, Ccta, ...
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Disease relevance of Tcp1

  • Multiple mutations in the t complex interact to alter profoundly the transmission ratio of t complex-bearing sperm or to cause complete sterility or semisterility [1].
  • We have cloned a cDNA for the 12.3kDa polypeptide (light chain 3) and found that this protein is highly homologous to mouse Tctex1, a protein encoded by a member of the multigene family in the t complex region that is involved in male sterility and the development of the germ cells [2].
  • On the basis of these studies, 5 patients with inoperable cholangiocarcinoma were treated with CCT for 4 weeks [3].
  • Adult mice lacking the p53/p63 target gene Perp are not predisposed to spontaneous tumorigenesis but display features of ectodermal dysplasia syndromes [4].
  • In addition, p63 has also been shown to play a role in cancer development through the differential regulation of genes with tumor suppressor function and genes involved in metastasis [5].

Psychiatry related information on Tcp1

  • p51A, or TAp63gamma, a translation product of gene p51, or p63, was identified as a homolog of p53 in its primary structure and transactivating function. p53 plays a decision-making role in inducing either cell cycle arrest or apoptosis in response to DNA damage, and thereby preserves genome integrity of living cells [6].

High impact information on Tcp1


Chemical compound and disease context of Tcp1


Biological context of Tcp1


Anatomical context of Tcp1

  • One of these, Tcp-1 has been cloned and shown to code for a protein probably essential for acrosome formation [12].
  • To determine whether p63/6.9 is a direct gene product of the T/t complex, testicular cytoplasmic RNA from mice bearing the genotypes +/+, +/t and t/t was translated in a rabbit reticulocyte-derived cell-free system, and translated products were analyzed by two-dimensional gel electrophoresis [14].
  • The expression levels of CCT subunits varied among seven mouse cell lines tested but showed a close correlation with growth rate [15].
  • Both the CCT protein and mRNA levels in the human promyelolytic cell HL60 decreased concomitant with growth arrest during differentiation [15].
  • All the CCT subunits contain motifs that are also shared by all other known chaperonins of prokaryotes and eukaryotic organelles, and that probably relate to their common ATPase function [16].

Associations of Tcp1 with chemical compounds

  • It is shown here that two genes located 3' to the murine Tcp-1 and Tcp-1x genes code for proteins highly homologous to acetyl-CoA acetyltransferases [10].
  • On the other hand, the CCT complex of asynchronous cells (a mixture of various phases of cell cycle) exhibited lower alpha and delta subunit content and lower chaperone activity than that of S-phase-arrested cells obtained by excess thymidine treatment [17].
  • The t-complex-encoded guanine nucleotide exchange factor Fgd2 reveals that two opposing signaling pathways promote transmission ratio distortion in the mouse [18].
  • They both have the unusual codon CCT for proline at position 7, which so far has been found only in a specific set of VH genes, called the NPb family [19].
  • In this investigation, we developed a new percutaneous transhepatic biliary drainage tube coated with carboplatin (carboplatin-coated tube; CCT) [3].

Other interactions of Tcp1


Analytical, diagnostic and therapeutic context of Tcp1


  1. tctex-1: a candidate gene family for a mouse t complex sterility locus. Lader, E., Ha, H.S., O'Neill, M., Artzt, K., Bennett, D. Cell (1989) [Pubmed]
  2. A dynein light chain of sea urchin sperm flagella is a homolog of mouse Tctex 1, which is encoded by a gene of the t complex sterility locus. Kagami, O., Gotoh, M., Makino, Y., Mohri, H., Kamiya, R., Ogawa, K. Gene (1998) [Pubmed]
  3. A study of carboplatin-coated tube for the unresectable cholangiocarcinoma. Mezawa, S., Homma, H., Sato, T., Doi, T., Miyanishi, K., Takada, K., Kukitsu, T., Murase, K., Yoshizaki, N., Takahashi, M., Sakamaki, S., Niitsu, Y. Hepatology (2000) [Pubmed]
  4. Adult mice lacking the p53/p63 target gene Perp are not predisposed to spontaneous tumorigenesis but display features of ectodermal dysplasia syndromes. Ihrie, R.A., Bronson, R.T., Attardi, L.D. Cell Death Differ. (2006) [Pubmed]
  5. Identification of vitamin D receptor as a target of p63. Kommagani, R., Caserta, T.M., Kadakia, M.P. Oncogene (2006) [Pubmed]
  6. p51A (TAp63gamma), a p53 homolog, accumulates in response to DNA damage for cell regulation. Katoh, I., Aisaki, K.I., Kurata, S.I., Ikawa, S., Ikawa, Y. Oncogene (2000) [Pubmed]
  7. The t complex polypeptide 1 (TCP-1) is associated with the cytoplasmic aspect of Golgi membranes. Willison, K., Lewis, V., Zuckerman, K.S., Cordell, J., Dean, C., Miller, K., Lyon, M.F., Marsh, M. Cell (1989) [Pubmed]
  8. Molecular cloning and sequence analysis of a haploid expressed gene encoding t complex polypeptide 1. Willison, K.R., Dudley, K., Potter, J. Cell (1986) [Pubmed]
  9. Identification of a locus on mouse chromosome 17 associated with high-affinity choline uptake using BXD recombinant inbred mice and quantitative trait loci analysis. Tarricone, B.J., Hwang, W.G., Hingtgen, J.N., Mitchell, S.R., Belknap, J.K., Nurnberger, J.I. Genomics (1995) [Pubmed]
  10. Two acetyl-CoA acetyltransferase genes located in the t-complex region of mouse chromosome 17 partially overlap the Tcp-1 and Tcp-1x genes. Ashworth, A. Genomics (1993) [Pubmed]
  11. Molecular characterization of four intra-t mouse recombinants. Mizuno, K., Vincek, V., Figueroa, F., Klein, J. Immunogenetics (1989) [Pubmed]
  12. Isolation and characterization of a cDNA clone corresponding to the mouse t-complex gene Tcp-1x. Dudley, K., Shanahan, F., Burtenshaw, M., Evans, E.P., Ruddy, S., Lyon, M.F. Genet. Res. (1991) [Pubmed]
  13. Quantitation of two-dimensional gel proteins reveals unequal amounts of Tcp-1 gene products during mouse spermatogenesis but no correlation with transmission ratio distortion. Sánchez, E.R., Hammerberg, C., Erickson, R.P. Journal of embryology and experimental morphology. (1985) [Pubmed]
  14. Cell-free translation of a T/t complex cell surface-associated gene product. Danska, J.S., Silver, L.M. Cell (1980) [Pubmed]
  15. Cytosolic chaperonin is up-regulated during cell growth. Preferential expression and binding to tubulin at G(1)/S transition through early S phase. Yokota, S., Yanagi, H., Yura, T., Kubota, H. J. Biol. Chem. (1999) [Pubmed]
  16. Identification of six Tcp-1-related genes encoding divergent subunits of the TCP-1-containing chaperonin. Kubota, H., Hynes, G., Carne, A., Ashworth, A., Willison, K. Curr. Biol. (1994) [Pubmed]
  17. Cytosolic chaperonin-containing t-complex polypeptide 1 changes the content of a particular subunit species concomitant with substrate binding and folding activities during the cell cycle. Yokota, S., Yanagi, H., Yura, T., Kubota, H. Eur. J. Biochem. (2001) [Pubmed]
  18. The t-complex-encoded guanine nucleotide exchange factor Fgd2 reveals that two opposing signaling pathways promote transmission ratio distortion in the mouse. Bauer, H., Véron, N., Willert, J., Herrmann, B.G. Genes Dev. (2007) [Pubmed]
  19. Allelic immunoglobulin VH genes in two mouse strains: possible germline gene recombination. Cohen, J.B., Givol, D. EMBO J. (1983) [Pubmed]
  20. Identification of the t complex-encoded cytoplasmic dynein light chain tctex1 in inner arm I1 supports the involvement of flagellar dyneins in meiotic drive. Harrison, A., Olds-Clarke, P., King, S.M. J. Cell Biol. (1998) [Pubmed]
  21. Is there a Brachyury the Second? Analysis of a transgenic mutation involved in notochord maintenance in mice. Rennebeck, G.M., Lader, E., Chen, Q., Bohm, R.A., Cai, Z.S., Faust, C., Magnuson, T., Pease, L.R., Artzt, K. Dev. Biol. (1995) [Pubmed]
  22. Genetic mapping of the t-complex region on mouse chromosome 17 including the Hybrid sterility-1 gene. Forejt, J., Vincek, V., Klein, J., Lehrach, H., Loudová-Micková, M. Mamm. Genome (1991) [Pubmed]
  23. Molecular structure of Tcp-10 genes from the t complex responder locus. Bullard, D.C., Schimenti, J.C. Mamm. Genome (1991) [Pubmed]
  24. Genetic analysis of the proximal portion of the mouse t complex: evidence for a second inversion within t haplotypes. Herrmann, B., Bućan, M., Mains, P.E., Frischauf, A.M., Silver, L.M., Lehrach, H. Cell (1986) [Pubmed]
  25. The human homologue of the mouse t-complex gene, TCP1, is located on chromosome 6 but is not near the HLA region. Willison, K., Kelly, A., Dudley, K., Goodfellow, P., Spurr, N., Groves, V., Gorman, P., Sheer, D., Trowsdale, J. EMBO J. (1987) [Pubmed]
  26. The cytosolic chaperonin CCT associates to cytoplasmic microtubular structures during mammalian spermiogenesis and to heterochromatin in germline and somatic cells. Souès, S., Kann, M.L., Fouquet, J.P., Melki, R. Exp. Cell Res. (2003) [Pubmed]
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