- Zolantidine (SK&F 95282) is a potent selective brain-penetrating histamine H2-receptor antagonist. Calcutt, C.R., Ganellin, C.R., Griffiths, R., Leigh, B.K., Maguire, J.P., Mitchell, R.C., Mylek, M.E., Parsons, M.E., Smith, I.R., Young, R.C. Br. J. Pharmacol. (1988)