The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

Zolantidine     N-[3-[3-(1-piperidylmethyl) phenoxy]propyl]...

Synonyms: Lopac-S-5317, Tocris-1070, CHEMBL419296, SKF-95282, CCG-205319, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of SKF-95282

  • The present results are the first to demonstrate the existence of brain-penetrating antinociceptive agents chemically related to zolantidine and improgan, but further studies are needed to understand the mechanisms of both the pain relief and toxicity produced by these agents [1].
  • The present study determined the effects of the brain-penetrating H2 receptor antagonist zolantidine (ZOL) on 2DG antinociception on the tail-flick and jump tests, as well as on 2DG hyperphagia, in rats [2].
  • Neither mepyramine, an H1 receptor blocker nor zolantidine, an H2 blocker provided any decrease in brain swelling or water content [3].

Psychiatry related information on SKF-95282


High impact information on SKF-95282


Biological context of SKF-95282


Anatomical context of SKF-95282


Associations of SKF-95282 with other chemical compounds


Gene context of SKF-95282


Analytical, diagnostic and therapeutic context of SKF-95282

  • Zolantidine inhibited the analgesia elicited by exposure to 3.5 mA for 3 min, with maximum inhibition observed 30 min after a dose of 5 mg/kg [9].


  1. Antinociceptive, brain-penetrating derivatives related to improgan, a non-opioid analgesic. Hough, L.B., Nalwalk, J.W., Lu, Q., Shan, Z., Svokos, K., Wentland, M.P., Montero, M.J. Eur. J. Pharmacol. (2005) [Pubmed]
  2. Potentiation of 2-deoxy-D-glucose antinociception, but not hyperphagia by zolantidine, a histamine (H2) receptor antagonist. Koch, J.E., Hough, L.B., Bodnar, R.J. Pharmacol. Biochem. Behav. (1992) [Pubmed]
  3. Effects of antihistaminics on experimental brain edema. Schilling, L., Wahl, M. Acta neurochirurgica. Supplementum. (1994) [Pubmed]
  4. Effects of histamine agents on methamphetamine-induced stereotyped behavior and behavioral sensitization in rats. Ito, C., Onodera, K., Watanabe, T., Sato, M. Psychopharmacology (Berl.) (1997) [Pubmed]
  5. Effects of intracerebroventricular injection of alpha-fluoromethylhistidine on radial maze performance in rats. Chen, Z., Sugimoto, Y., Kamei, C. Pharmacol. Biochem. Behav. (1999) [Pubmed]
  6. Sleep variables are unaltered by zolantidine in rats: are histamine H2-receptors not involved in sleep regulation? Monti, J.M., Orellana, C., Boussard, M., Jantos, H., Olivera, S. Brain Res. Bull. (1990) [Pubmed]
  7. Effects of thioperamide, a histamine H3 receptor antagonist, on locomotor activity and brain histamine content in mast cell-deficient W/Wv mice. Sakai, N., Onodera, K., Maeyama, K., Yanai, K., Watanabe, T. Life Sci. (1991) [Pubmed]
  8. Histamine H(2) -like receptors in chick cerebral cortex: effects on cyclic AMP synthesis and characterization by [(3) H]tiotidine binding. Zawilska, J.B., Woldan-Tambor, A., Nowak, J.Z. J. Neurochem. (2002) [Pubmed]
  9. Effects of zolantidine a brain-penetrating H2-receptor antagonist, on naloxone-sensitive and naloxone-resistant analgesia. Gogas, K.R., Hough, L.B. Neuropharmacology (1988) [Pubmed]
  10. Actions of the brain-penetrating H2-antagonist zolantidine on histamine dynamics and metabolism in rat brain. Hough, L.B., Jackowski, S., Eberle, N., Gogas, K.R., Camarota, N.A., Cue, D. Biochem. Pharmacol. (1988) [Pubmed]
  11. Zolantidine (SK&F 95282) is a potent selective brain-penetrating histamine H2-receptor antagonist. Calcutt, C.R., Ganellin, C.R., Griffiths, R., Leigh, B.K., Maguire, J.P., Mitchell, R.C., Mylek, M.E., Parsons, M.E., Smith, I.R., Young, R.C. Br. J. Pharmacol. (1988) [Pubmed]
  12. Activity of the new histamine H2-receptor antagonist zolantidine at cardiac and gastric H2-receptors. Coruzzi, G., Adami, M., Pozzoli, C., Poli, E., Bertaccini, G. Pharmacology (1994) [Pubmed]
  13. Effects of the histaminergic system on the morphine-induced conditioned place preference in mice. Suzuki, T., Takamori, K., Misawa, M., Onodera, K. Brain Res. (1995) [Pubmed]
  14. Inhibition of morphine antinociception by centrally administered histamine H2 receptor antagonists. Hough, L.B., Nalwalk, J.W. Eur. J. Pharmacol. (1992) [Pubmed]
  15. The involvement of histamine H2-receptors in restraint-induced antinociception in male mice. Wong, C.L. Methods and findings in experimental and clinical pharmacology. (1993) [Pubmed]
  16. Different effects of the histamine H2 receptor blockers, famotidine and zolantidine, on the human atrium in vitro. Poli, E., Pozzoli, C., Barboso, G., Bertaccini, G. Archives internationales de pharmacodynamie et de thérapie. (1994) [Pubmed]
  17. Aminergic control of high-frequency (approximately 200 Hz) network oscillations in the hippocampus of the behaving rat. Ponomarenko, A.A., Knoche, A., Korotkova, T.M., Haas, H.L. Neurosci. Lett. (2003) [Pubmed]
  18. Role of the histamine system in nefopam-induced antinociception in mice. Girard, P., Pansart, Y., Coppé, M.C., Verniers, D., Gillardin, J.M. Eur. J. Pharmacol. (2004) [Pubmed]
  19. Effects of thioperamide, a histamine H3-receptor antagonist, on a scopolamine-induced learning deficit using an elevated plus-maze test in mice. Miyazaki, S., Imaizumi, M., Onodera, K. Life Sci. (1995) [Pubmed]
  20. Effects of thioperamide on the cholinergic system and the step-through passive avoidance test in mice. Miyazaki, S., Imaizumi, M., Onodera, K. Methods and findings in experimental and clinical pharmacology. (1995) [Pubmed]
  21. Histamine receptors in the central nervous system. Timmerman, H. Pharmaceutisch weekblad. Scientific edition. (1989) [Pubmed]
WikiGenes - Universities