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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Splanchnic nerve activation inhibits the increase in duodenal HCO3- secretion induced by luminal acidification in the rat.

Acid exposure of the duodenal mucosa increased duodenal HCO3- secretion by approximately 60%. When the acid exposure was performed simultaneously with an arterial bleeding of 0.6 ml/100 g body wt (10% of the total blood volume), the increase in duodenal HCO3- secretion was totally abolished. When the acid exposure and bleeding procedures were performed at the same time in rats with bilaterally cut splanchnic nerves, alkaline secretion increased by 60%, as it did in the unbled rats. Direct electrical stimulation of the splanchnic nerves (10 Hz, supramaximal intensity) inhibited the stimulatory effect of duodenal acid exposure on alkaline secretion. Taken together, the data suggest that the sympathetic nervous system, because of splanchnic nerve activation, inhibits the acid-induced increase in duodenal HCO3- secretion.[1]


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