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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Trans-activator gene of HTLV-II induces IL-2 receptor and IL-2 cellular gene expression.

The human T-lymphotropic viruses types I and II (HTLV-I and -II) have been etiologically linked with certain T-cell leukemias and lymphomas that characteristically display membrane receptors for interleukin-2. The relation of these viruses to this growth factor receptor has remained unexplained. It is demonstrated here that introduction of the trans-activator (tat) gene of HTLV-II into the Jurkat T-lymphoid cell line results in the induction of both interleukin-2 receptor and interleukin-2 gene expression. The coexpression of these cellular genes may play a role in the altering T-cell growth following retroviral infection.[1]

References

  1. Trans-activator gene of HTLV-II induces IL-2 receptor and IL-2 cellular gene expression. Greene, W.C., Leonard, W.J., Wano, Y., Svetlik, P.B., Peffer, N.J., Sodroski, J.G., Rosen, C.A., Goh, W.C., Haseltine, W.A. Science (1986) [Pubmed]
 
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