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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Genes, tat

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Disease relevance of Genes, tat


High impact information on Genes, tat


Chemical compound and disease context of Genes, tat

  • HeLa cells were coelectroporated with two plasmids, one containing the HIV tat gene in an expression cassette and another containing the dominant selectable marker gene xanthine guanine phosphoribosyltransferase (XGPRT) [11].
  • HIV-1 Tat (1-72) and a mutant Tat lacking five cysteine residues were cloned into the pAK phagemid system, which allows fusion of the tat gene to a supershort version of the gene for minor M13 coat protein [12].

Biological context of Genes, tat


Anatomical context of Genes, tat


Associations of Genes, tat with chemical compounds

  • An important component of glucocorticoid steroid induction of tyrosine aminotransferase (TAT) gene expression is the glucocorticoid modulatory element (GME), which is located at -3.6 kb of the rat TAT gene [20].
  • Replication in goats in vivo of caprine arthritis-encephalitis virus deleted in vif or tat genes: possible use of these deletion mutants as live vaccines [21].

Gene context of Genes, tat


  1. In vivo protein-DNA interactions in a glucocorticoid response element require the presence of the hormone. Becker, P.B., Gloss, B., Schmid, W., Strähle, U., Schütz, G. Nature (1986) [Pubmed]
  2. Exonic splicing enhancer motif recognized by human SC35 under splicing conditions. Liu, H.X., Chew, S.L., Cartegni, L., Zhang, M.Q., Krainer, A.R. Mol. Cell. Biol. (2000) [Pubmed]
  3. Inhibition of tyrosine aminotransferase gene expression by retinoic acid. Pan, C.J., Shelly, L.L., Rabin, D.S., Chou, J.Y. Mol. Endocrinol. (1992) [Pubmed]
  4. The caprine arthritis encephalitis virus tat gene is dispensable for efficient viral replication in vitro and in vivo. Harmache, A., Vitu, C., Russo, P., Bouyac, M., Hieblot, C., Peveri, P., Vigne, R., Suzan, M. J. Virol. (1995) [Pubmed]
  5. Bovine immunodeficiency-like virus encodes factors which trans activate the long terminal repeat. Pallansch, L.A., Lackman-Smith, C.S., Gonda, M.A. J. Virol. (1992) [Pubmed]
  6. In vivo footprinting of rat TAT gene: dynamic interplay between the glucocorticoid receptor and a liver-specific factor. Rigaud, G., Roux, J., Pictet, R., Grange, T. Cell (1991) [Pubmed]
  7. A cyclic AMP response element mediates repression of tyrosine aminotransferase gene transcription by the tissue-specific extinguisher locus Tse-1. Boshart, M., Weih, F., Schmidt, A., Fournier, R.E., Schütz, G. Cell (1990) [Pubmed]
  8. Control of human immunodeficiency virus replication by the tat, rev, nef and protease genes. Karn, J. Curr. Opin. Immunol. (1991) [Pubmed]
  9. Activation of interleukin 2 and interleukin 2 receptor (Tac) promoter expression by the trans-activator (tat) gene product of human T-cell leukemia virus, type I. Siekevitz, M., Feinberg, M.B., Holbrook, N., Wong-Staal, F., Greene, W.C. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
  10. The maedi-visna virus Tat protein induces multiorgan lymphoid hyperplasia in transgenic mice. Vellutini, C., Philippon, V., Gambarelli, D., Horschowski, N., Nave, K.A., Navarro, J.M., Auphan, M., Courcoul, M.A., Filippi, P. J. Virol. (1994) [Pubmed]
  11. Alterations in tumor angiogenesis associated with stable expression of the HIV tat gene. Huber, B.E., Richards, C.A., Martin, J.L., Wirth, P.J. Mol. Carcinog. (1992) [Pubmed]
  12. A selection system to study protein-RNA interactions: functional display of HIV-1 Tat protein on filamentous bacteriophage M13. Hoffmann, S., Willbold, D. Biochem. Biophys. Res. Commun. (1997) [Pubmed]
  13. Glucocorticoid-induced DNA demethylation and gene memory during development. Thomassin, H., Flavin, M., Espinás, M.L., Grange, T. EMBO J. (2001) [Pubmed]
  14. Chromatin structures of the rat tyrosine aminotransferase gene relate to the function of its cis-acting elements. Nitsch, D., Stewart, A.F., Boshart, M., Mestril, R., Weih, F., Schütz, G. Mol. Cell. Biol. (1990) [Pubmed]
  15. Synthetic glucocorticoids that dissociate transactivation and AP-1 transrepression exhibit antiinflammatory activity in vivo. Vayssière, B.M., Dupont, S., Choquart, A., Petit, F., Garcia, T., Marchandeau, C., Gronemeyer, H., Resche-Rigon, M. Mol. Endocrinol. (1997) [Pubmed]
  16. A BAM HI RFLP at the human tyrosine aminotransferase (TAT) gene locus at 16q. Wullich, B., Natt, E., Wienker, T.F., Scherer, G. Nucleic Acids Res. (1989) [Pubmed]
  17. mRNA levels and methylation patterns of the tyrosine aminotransferase gene in aging inbred rats. Slagboom, P.E., de Leeuw, W.J., Vijg, J. FEBS Lett. (1990) [Pubmed]
  18. Hepatocyte differentiation in vitro: initiation of tyrosine aminotransferase expression in cultured fetal rat hepatocytes. Shelly, L.L., Tynan, W., Schmid, W., Schütz, G., Yeoh, G.C. J. Cell Biol. (1989) [Pubmed]
  19. Ablation of stimulation of a cAMP-responsive promoter in CHO cell lines defective in their cAMP-dependent protein kinase system. Fleischmann, R.D., Jeng, C., Gottesman, M.M. Somat. Cell Mol. Genet. (1992) [Pubmed]
  20. Properties of the glucocorticoid modulatory element binding proteins GMEB-1 and -2: potential new modifiers of glucocorticoid receptor transactivation and members of the family of KDWK proteins. Kaul, S., Blackford, J.A., Chen, J., Ogryzko, V.V., Simons, S.S. Mol. Endocrinol. (2000) [Pubmed]
  21. Replication in goats in vivo of caprine arthritis-encephalitis virus deleted in vif or tat genes: possible use of these deletion mutants as live vaccines. Harmache, A., Russo, P., Vitu, C., Guiguen, F., Mornex, J.F., Pepin, M., Vigne, R., Suzan, M. AIDS Res. Hum. Retroviruses (1996) [Pubmed]
  22. Isolation, characterization and chromosomal mapping of the mouse tyrosine aminotransferase gene. Müller, G., Scherer, G., Zentgraf, H., Ruppert, S., Herrmann, B., Lehrach, H., Schütz, G. J. Mol. Biol. (1985) [Pubmed]
  23. Transcriptional up-regulation of interleukin 4 receptors by human immunodeficiency virus type 1 tat gene. Husain, S.R., Leland, P., Aggarwal, B.B., Puri, R.K. AIDS Res. Hum. Retroviruses (1996) [Pubmed]
  24. Tetrahydrogestrinone is a potent but unselective binding steroid and affects glucocorticoid signalling in the liver. Friedel, A., Geyer, H., Kamber, M., Laudenbach-Leschowsky, U., Schänzer, W., Thevis, M., Vollmer, G., Zierau, O., Diel, P. Toxicol. Lett. (2006) [Pubmed]
  25. Aggregate cultures of foetal rat liver cells: development and maintenance of liver gene expression. Guigoz, Y., Werffeli, P., Favre, D., Juillerat, M., Wellinger, R., Honegger, P. Biol. Cell (1987) [Pubmed]
  26. Replication and pathogenesis of the human T-cell leukemia/lymphotropic retroviruses. Haseltine, W., Sodroski, J., Rosen, C. Haematology and blood transfusion. (1987) [Pubmed]
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