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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Conservative treatment for breast cancer. Complications requiring reconstructive surgery.

Women who select conservative treatment for carcinoma of the breast (tumor excision followed by supervoltage radiation therapy) place a premium on breast preservation and aesthetics. When local control fails and they require a mastectomy, or when the aesthetic appearance is unacceptable, they may request breast reconstruction. The goal of this study is to evaluate a series of 10 patients who required reconstructive breast surgery after complications of conservative treatment. Patient classification: I. Breast or chest wall necrosis (3). II. Breast fibrosis and gross asymmetry (3). III. Local recurrence of breast cancer (5). IV. Positive margins after the initial lumpectomy (1). The mean age was 34 years. Radiation dosage average was 5252 rads with two patients receiving iridium-192 implant boosts. The reconstructive management was complex and usually required a major musculocutaneous flap because of the radiation effects.[1]


  1. Conservative treatment for breast cancer. Complications requiring reconstructive surgery. Bostwick, J., Paletta, C., Hartrampf, C.R. Ann. Surg. (1986) [Pubmed]
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