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MeSH Review


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Disease relevance of Mammaplasty


Psychiatry related information on Mammaplasty

  • The information needs of women who have undergone breast reconstruction. Part I: decision-making and sources of information [6].
  • Application of this method suggests that patients requesting reduction or augmentation mammaplasty on the NHS represent a significant deviation from 'normal' morphometry and do not simply have a subjective distortion of their own body image [7].

High impact information on Mammaplasty

  • RESULTS: CRBP was expressed in all 15 mammoplasty specimens (normal breast tissue) and in 33 of 35 available specimens of normal tissue adjacent to carcinoma [8].
  • Proteomic definition of normal human luminal and myoepithelial breast cells purified from reduction mammoplasties [9].
  • Cells derived from (normal) breast mammoplasty specimens and grown on the surface of collagen gels exhibited three major classes of plasminogen activator isozymes (Mr = 100,000 [100K], 75,000 [75K], and 55,000 [55K]) [10].
  • In contrast, low phospho-p38 staining was observed in the majority of normal tissue obtained from reduction mammoplasty [11].
  • Most importantly, the expression of RANTES was minimally detected in sections of patients diagnosed with benign breast disorders and of women that underwent reduction mammoplasty (15.4% of the cases) [12].

Chemical compound and disease context of Mammaplasty


Biological context of Mammaplasty


Anatomical context of Mammaplasty


Associations of Mammaplasty with chemical compounds


Gene context of Mammaplasty

  • We conclude that much useful information about P450 in the breast can be obtained from reduction mammaplasty samples [3].
  • Characterization of cytochrome P450 enzymes in human breast tissue from reduction mammaplasties [3].
  • As previously observed, IL-6+IL-6sR markedly stimulated aromatase activity (7.7-20.8-fold) in fibroblasts derived from reduction mammoplasty tissue, tissue proximal to tumours and breast tumours [30].
  • Aromatase activity and IL-6 production were also measured in tissue obtained from a normal woman undergoing reduction mammoplasty who had previously had breast augmentation by silicone injection, not contained within a capsule [31].
  • This study describes the profile of VEGF production in human surgical wounds in both breast cancer patients and reduction mammoplasty controls, and assesses the changes in systemic VEGF levels and platelet profiles perioperatively [32].

Analytical, diagnostic and therapeutic context of Mammaplasty


  1. Effect of estradiol on nonmalignant human mammary cells in primary culture. Chambon, M., Cavalie-Barthez, G., Veith, F., Vignon, F., Hallowes, R., Rochefort, H. Cancer Res. (1984) [Pubmed]
  2. Regulated CYP19 aromatase transcription in breast stromal fibroblasts. Pauley, R.J., Santner, S.J., Tait, L.R., Bright, R.K., Santen, R.J. J. Clin. Endocrinol. Metab. (2000) [Pubmed]
  3. Characterization of cytochrome P450 enzymes in human breast tissue from reduction mammaplasties. Hellmold, H., Rylander, T., Magnusson, M., Reihnér, E., Warner, M., Gustafsson, J.A. J. Clin. Endocrinol. Metab. (1998) [Pubmed]
  4. Late capsular hematoma after breast reconstruction with polyurethane-covered implants. Wang, B.H., Chang, B.W., Sargeant, R., Manson, P.N. Plast. Reconstr. Surg. (1998) [Pubmed]
  5. Hernia prevention and aesthetic contouring of the abdomen following TRAM flap breast reconstruction by the use of polypropylene mesh. Zienowicz, R.J., May, J.W. Plast. Reconstr. Surg. (1995) [Pubmed]
  6. The information needs of women who have undergone breast reconstruction. Part I: decision-making and sources of information. Wolf, L. European journal of oncology nursing : the official journal of European Oncology Nursing Society. (2004) [Pubmed]
  7. A method of assessing female breast morphometry and its clinical application. Brown, T.P., Ringrose, C., Hyland, R.E., Cole, A.A., Brotherston, T.M. British journal of plastic surgery. (1999) [Pubmed]
  8. Cellular retinol-binding protein expression and breast cancer. Kuppumbatti, Y.S., Bleiweiss, I.J., Mandeli, J.P., Waxman, S., Mira-Y-Lopez, R. J. Natl. Cancer Inst. (2000) [Pubmed]
  9. Proteomic definition of normal human luminal and myoepithelial breast cells purified from reduction mammoplasties. Page, M.J., Amess, B., Townsend, R.R., Parekh, R., Herath, A., Brusten, L., Zvelebil, M.J., Stein, R.C., Waterfield, M.D., Davies, S.C., O'Hare, M.J. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  10. Effect of the extracellular matrix on plasminogen activator isozyme activities of human mammary epithelial cells in culture. Yang, N.S., Park, C., Longley, C., Furmanski, P. Mol. Cell. Biol. (1983) [Pubmed]
  11. p38 regulates cyclooxygenase-2 in human mammary epithelial cells and is activated in premalignant tissue. Gauthier, M.L., Pickering, C.R., Miller, C.J., Fordyce, C.A., Chew, K.L., Berman, H.K., Tlsty, T.D. Cancer Res. (2005) [Pubmed]
  12. Elevated expression of the CC chemokine regulated on activation, normal T cell expressed and secreted (RANTES) in advanced breast carcinoma. Luboshits, G., Shina, S., Kaplan, O., Engelberg, S., Nass, D., Lifshitz-Mercer, B., Chaitchik, S., Keydar, I., Ben-Baruch, A. Cancer Res. (1999) [Pubmed]
  13. Incidence of hematoma associated with ketorolac after TRAM flap breast reconstruction. Sharma, S., Chang, D.W., Koutz, C., Evans, G.R., Robb, G.L., Langstein, H.N., Kroll, S.S. Plast. Reconstr. Surg. (2001) [Pubmed]
  14. Randomized, double-blind trial of dolasetron versus droperidol for prophylaxis of postoperative nausea and vomiting in patients undergoing TRAM flap breast reconstruction surgery. Loewen, P., Lamb, S., Clugston, P. Annals of plastic surgery. (2003) [Pubmed]
  15. Effect of cortisone on capsular contracture in double-lumen breast implants: ten years' experience. Lemperle, G., Exner, K. Aesthetic plastic surgery. (1993) [Pubmed]
  16. DNA methylation in the promoter region of the p16 (CDKN2/MTS-1/INK4A) gene in human breast tumours. Woodcock, D.M., Linsenmeyer, M.E., Doherty, J.P., Warren, W.D. Br. J. Cancer (1999) [Pubmed]
  17. Soy isoflavone genistein modulates cell cycle progression and induces apoptosis in HER-2/neu oncogene expressing human breast epithelial cells. Katdare, M., Osborne, M., Telang, N.T. Int. J. Oncol. (2002) [Pubmed]
  18. Smoking and wound healing problems in reduction mammaplasty: is the introduction of urine nicotine testing justified? Chan, L.K., Withey, S., Butler, P.E. Annals of plastic surgery. (2006) [Pubmed]
  19. Comparison of intravenous patient-controlled analgesia with tramadol versus morphine after microvascular breast reconstruction. Silvasti, M., Svartling, N., Pitkänen, M., Rosenberg, P.H. European journal of anaesthesiology. (2000) [Pubmed]
  20. 32P-postlabelling determination of DNA adducts of malonaldehyde in humans: total white blood cells and breast tissue. Vaca, C.E., Fang, J.L., Mutanen, M., Valsta, L. Carcinogenesis (1995) [Pubmed]
  21. N-Acetyltransferases, sulfotransferases and heterocyclic amine activation in the breast. Williams, J.A., Stone, E.M., Fakis, G., Johnson, N., Cordell, J.A., Meinl, W., Glatt, H., Sim, E., Phillips, D.H. Pharmacogenetics (2001) [Pubmed]
  22. Estrone formation from dehydroepiandrosterone in cultured human breast adipose stromal cells. Killinger, D.W., Strutt, B.J., Roncari, D.A., Khalil, M.W. J. Steroid Biochem. Mol. Biol. (1995) [Pubmed]
  23. Use of synthetic mesh for the entire abdominal wall after TRAM flap transfer. Moscona, R.A., Ramon, Y., Toledano, H., Barzilay, G. Plast. Reconstr. Surg. (1998) [Pubmed]
  24. An ipsilateral superdrainaged transverse rectus abdominis myocutaneous flap for breast reconstruction. Yanaga, H., Tai, Y., Kiyokawa, K., Inoue, Y., Rikimaru, H. Plast. Reconstr. Surg. (1999) [Pubmed]
  25. Estradiol and progesterone receptors in cultured normal human breast epithelial cells and fibroblasts: immunocytochemical studies. Malet, C., Gompel, A., Yaneva, H., Cren, H., Fidji, N., Mowszowicz, I., Kuttenn, F., Mauvais-Jarvis, P. J. Clin. Endocrinol. Metab. (1991) [Pubmed]
  26. Bilateral reduction mammoplasty in a patient treated with calcium channel blocker and cyclosporine after renal transplant: a case report. Pan, Y., Grindstaff, A., Cassada, D., Goldman, M., Taylor, J. Transplantation (1997) [Pubmed]
  27. Paravertebral analgesia with levobupivacaine increases postoperative flap tissue oxygen tension after immediate latissimus dorsi breast reconstruction compared with intravenous opioid analgesia. Buggy, D.J., Kerin, M.J. Anesthesiology (2004) [Pubmed]
  28. Effect of infiltration with ropivacaine on blood loss during reduction mammoplasty. Liddle, A.M., Hall, A.P., Arrowsmith, J., Smith, G. British journal of anaesthesia. (1998) [Pubmed]
  29. In vitro cutaneous and percutaneous delivery and in vivo efficacy of tetracaine from liposomal and conventional vehicles. Foldvari, M. Pharm. Res. (1994) [Pubmed]
  30. Inhibition of IL-6+IL-6 soluble receptor-stimulated aromatase activity by the IL-6 antagonist, Sant 7, in breast tissue-derived fibroblasts. Purohit, A., Singh, A., Ghilchik, M.W., Serlupi-Crescenzi, O., Reed, M.J. Br. J. Cancer (2003) [Pubmed]
  31. Aromatase activity and interleukin-6 production by normal and malignant breast tissues. Purohit, A., Ghilchik, M.W., Duncan, L., Wang, D.Y., Singh, A., Walker, M.M., Reed, M.J. J. Clin. Endocrinol. Metab. (1995) [Pubmed]
  32. The relationship of human wound vascular endothelial growth factor (VEGF) after breast cancer surgery to circulating VEGF and angiogenesis. Hormbrey, E., Han, C., Roberts, A., McGrouther, D.A., Harris, A.L. Clin. Cancer Res. (2003) [Pubmed]
  33. Laparoscopic cholecystectomy following autogenous breast reconstruction with a TRAM flap. Williams, J.K., Bostwick, J., Daneker, G., Fink, A. Surgical endoscopy. (1995) [Pubmed]
  34. Thoracic epidural anesthesia for bilateral reduction mammoplasty in a patient with Klippel-Feil syndrome. O'Connor, P.J., Moysa, G.L., Finucane, B.T. Anesth. Analg. (2001) [Pubmed]
  35. Analgesic efficacy of diclofenac in combination with morphine and paracetamol after mastectomy and immediate breast reconstruction. Legeby, M., Sandelin, K., Wickman, M., Olofsson, C. Acta anaesthesiologica Scandinavica. (2005) [Pubmed]
  36. Late side effects related to inflatable breast prostheses containing soluble steroids. Oneal, R.M., Argenta, L.C. Plast. Reconstr. Surg. (1982) [Pubmed]
  37. A comparison of outcomes using three different methods of breast reconstruction. Kroll, S.S., Baldwin, B. Plast. Reconstr. Surg. (1992) [Pubmed]
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