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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 

Purinogenic immunodeficiency diseases: selective toxicity of deoxyribonucleosides for T cells.

Deoxyadenosine at low concentrations and in the presence of an inhibitor of adenosine deaminase (adenosine aminohydrolase, EC 3.5.4.4) is markedly toxic to lymphoblast cell lines of T cell origin but does not impair growth of B cell lines. Deoxyguanosine is also more toxic for T lymphoblasts. In the presence of deoxyadenosine or deoxyguanosine, elevation of the corresponding deoxyribonucleoside triphosphate (dATP or dGTP) occurs in T cell, but not in B cell, lines. The addition of deoxycytidine or dipyridamole results in lower dATP and dGTP levels and prevents deoxyribonucleoside toxicity. These findings provide a molecular basis for the immunodeficiency observed in individuals with several inborn errors of purine metabolism.[1]

References

  1. Purinogenic immunodeficiency diseases: selective toxicity of deoxyribonucleosides for T cells. Mitchell, B.S., Mejias, E., Daddona, P.E., Kelley, W.N. Proc. Natl. Acad. Sci. U.S.A. (1978) [Pubmed]
 
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