Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Hermann, B.P. et al.

Wisconsin Card Sorting Test performance in patients with complex partial seizures of temporal-lobe origin.

Wisconsin Card Sorting Test (WCST) performance was investigated in patients with complex partial seizures (CPS) of dominant (n = 16) or nondominant (n = 19) temporal-lobe origin as well as in an epilepsy control group (n = 6) which consisted largely of patients with primary generalized epilepsies. Fifty seven percent of the CPS group (39% of dominant and 74% of nondominant temporal-lobe patients) performed in a manner suggestive of frontal-lobe pathology compared to 17% of the epilepsy controls. There were no differences among the groups in the number of categories achieved, but there were substantial qualitative differences in problem-solving efficiency. Nondominant temporal patients manifested more total errors and perseverative errors relative to both dominant temporal and epilepsy controls, and more perseverative responses relative to epilepsy controls. Dominant temporal-lobe patients showed more perseverative errors than epilepsy controls. Finally, a consecutive series of patients who underwent partial temporal-lobe resection were examined 6 months post-surgically and they were found to manifest significantly fewer perseverative responses. The possible reasons for "frontal-like" performance in CPS patients with documented temporal-lobe pathology are discussed and a specific hypothesis is suggested.[1]

References

Wisconsin Card Sorting Test performance in patients with complex partial seizures of temporal-lobe origin. Hermann, B.P., Wyler, A.R., Richey, E.T. Journal of clinical and experimental neuropsychology : official journal of the International Neuropsychological Society. (1988) [Pubmed]

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