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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Trimetrexate: a new antifol entering clinical trials.

Trimetrexate, a 2,4-diaminoquinazoline derivative, is a new antifol recently introduced into clinical trials. It differs from methotrexate principally in its transport (not carrier-mediated), and its intracellular retention (not polyglutamylated). Trimetrexate is active against tumors which are methotrexate-resistant on the basis of impaired transport, and has a broader range of antitumor activity in preclinical models. Animal studies predict toxicity principally to the central nervous system, gastrointestinal tract and bone marrow.[1]

References

  1. Trimetrexate: a new antifol entering clinical trials. O'Dwyer, P.J., Shoemaker, D.D., Plowman, J., Cradock, J., Grillo-Lopez, A., Leyland-Jones, B. Investigational new drugs. (1985) [Pubmed]
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