The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

trimetrexate     5-methyl-6-[[(3,4,5- trimethoxyphenyl)amino...

Synonyms: Trimetrexato, Trimetrexatum, Jb-11, CI-898, NSC-249008, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of trimetrexate

  • Next, human HCT-8 and HCT-116 colon cancer cells retrovirally transduced to express a DHFR-herpes simplex virus 1 thymidine kinase (HSV1 TK) fusion protein and treated with the DHFR inhibitor TMTX exhibited increased levels of the DHFR-HSV1 TK fusion protein and an increase in ganciclovir sensitivity by 250-fold [1].

High impact information on trimetrexate


Analytical, diagnostic and therapeutic context of trimetrexate

  • In a xenograft model, nude rats bearing DHFR-HSV1 TK-transduced HCT-8 tumors and treated with TMTX showed, after 24 h, a 2- to 4-fold increase of fusion-protein levels in tumor tissue from treated animals compared with controls, as determined by Western blotting [1].


  1. Cells exposed to antifolates show increased cellular levels of proteins fused to dihydrofolate reductase: a method to modulate gene expression. Mayer-Kuckuk, P., Banerjee, D., Malhotra, S., Doubrovin, M., Iwamoto, M., Akhurst, T., Balatoni, J., Bornmann, W., Finn, R., Larson, S., Fong, Y., Gelovani Tjuvajev, J., Blasberg, R., Bertino, J.R. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  2. Cell cycle effects of trimetrexate (CI-898). Hook, K.E., Nelson, J.M., Roberts, B.J., Griswold, D.P., Leopold, W.R. Cancer Chemother. Pharmacol. (1986) [Pubmed]
  3. Trimetrexate glucuronate associated with anti-Kaposi sarcoma effect. Harris, P.J. AIDS patient care and STDs. (1996) [Pubmed]
WikiGenes - Universities