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Chemical Compound Review

trimetrexate     5-methyl-6-[[(3,4,5- trimethoxyphenyl)amino...

Synonyms: Trimetrexato, Trimetrexatum, Jb-11, CI-898, NSC-249008, ...
 
 
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Disease relevance of trimetrexate

  • Next, human HCT-8 and HCT-116 colon cancer cells retrovirally transduced to express a DHFR-herpes simplex virus 1 thymidine kinase (HSV1 TK) fusion protein and treated with the DHFR inhibitor TMTX exhibited increased levels of the DHFR-HSV1 TK fusion protein and an increase in ganciclovir sensitivity by 250-fold [1].
 

High impact information on trimetrexate

 

Analytical, diagnostic and therapeutic context of trimetrexate

  • In a xenograft model, nude rats bearing DHFR-HSV1 TK-transduced HCT-8 tumors and treated with TMTX showed, after 24 h, a 2- to 4-fold increase of fusion-protein levels in tumor tissue from treated animals compared with controls, as determined by Western blotting [1].

References

  1. Cells exposed to antifolates show increased cellular levels of proteins fused to dihydrofolate reductase: a method to modulate gene expression. Mayer-Kuckuk, P., Banerjee, D., Malhotra, S., Doubrovin, M., Iwamoto, M., Akhurst, T., Balatoni, J., Bornmann, W., Finn, R., Larson, S., Fong, Y., Gelovani Tjuvajev, J., Blasberg, R., Bertino, J.R. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  2. Cell cycle effects of trimetrexate (CI-898). Hook, K.E., Nelson, J.M., Roberts, B.J., Griswold, D.P., Leopold, W.R. Cancer Chemother. Pharmacol. (1986) [Pubmed]
  3. Trimetrexate glucuronate associated with anti-Kaposi sarcoma effect. Harris, P.J. AIDS patient care and STDs. (1996) [Pubmed]
 
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