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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Hormonal control of the expression of antibody-defined lactosaminoglycans in the mouse uterus.

The uterus undergoes a number of hormone-induced changes during estrus and early pregnancy. Changes in the uterine glycoprotein population have been investigated by using the monoclonal antibodies SSEA-1, IIC 3, A5, and C6. These antibodies detect specific terminal or side-chain modifications of lactosaminoglycan molecules. In ovariectomized female mice treated with estrogen, SSEA-1 was the only antigen expressed at the uterine epithelium. Progestational stimuli for 2 days induced SSEA-1 expression in the uterine glands and the sialylated form of A5 at the uterine epithelium. Three days of progesterone treatment induced IIC3 expression within the uterine glands. An additional day of progesterone treatment resulted in a uterine epithelial expression of IIC3. The expression of these antigens in the progestational phase were confirmed in naturally mated females. In these preparations, expression of the sialylated form of C6 was also observed, beginning on Day 2.0 of gestation. These observations suggest subtle modification of lactosaminoglycan chains during the hormonally induced preparative and receptive phases of the mouse uterus.[1]


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