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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

The asymptomatic patient with a positive VDRL test.

Although VDRL and RPR tests are excellent screens for syphilis, false-positive reactions do occur. A positive VDRL or RPR test must be confirmed with an FTA-ABS test. Patients with positive serologic tests should have a thorough physical examination to determine the stage of syphilis. A patient with a low-titer VDRL or RPR may have active disease and may require lumbar puncture to rule out neurosyphilis.[1]


  1. The asymptomatic patient with a positive VDRL test. Feder, H.M., Manthous, C. American family physician. (1988) [Pubmed]
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