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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Neurosyphilis


Psychiatry related information on Neurosyphilis


High impact information on Neurosyphilis

  • Minocycline for symptomatic neurosyphilis in patients allergic to penicillin [6].
  • We examined the response to treatment with high-dose penicillin G in HIV-infected patients with symptomatic neurosyphilis [7].
  • The diagnosis of a toxic reaction to isoniazid was delayed by the possibility of concurrent active neurosyphilis and the failure to initially consider isoniazid poisoning in a patient without a history of sudden isoniazid overdose [8].
  • Our case suggests that while severe neurosyphilis can occur in HIV-infected persons with normal absolute CD4 counts, the percentage of CD4 cells may be a better indicator of the risk of neurosyphilis [9].
  • Two years later, reevaluation revealed active neurosyphilis in the freshly drawn and stored serum and CSF samples [10].

Chemical compound and disease context of Neurosyphilis


Biological context of Neurosyphilis

  • CASE SUMMARY: A 45-year-old HIV-positive man (CD4+ count 450 cells/mm(3) and history of AIDS-defining illness) presented with JHR after an initial intravenous dose of penicillin G for presumed neurosyphilis [16].
  • On the basis of this case and similar cases reported in the literature, we conclude that most, if not all, human immunodeficiency virus-infected patients with symptomatic neurosyphilis will have an elevated serum and CSF syphilis serology [17].

Anatomical context of Neurosyphilis


Gene context of Neurosyphilis


Analytical, diagnostic and therapeutic context of Neurosyphilis


  1. Invasion of the central nervous system by Treponema pallidum: implications for diagnosis and treatment. Lukehart, S.A., Hook, E.W., Baker-Zander, S.A., Collier, A.C., Critchlow, C.W., Handsfield, H.H. Ann. Intern. Med. (1988) [Pubmed]
  2. Response of latent syphilis or neurosyphilis to ceftriaxone therapy in persons infected with human immunodeficiency virus. Dowell, M.E., Ross, P.G., Musher, D.M., Cate, T.R., Baughn, R.E. Am. J. Med. (1992) [Pubmed]
  3. Neurosyphilis. Simon, R.P. Arch. Neurol. (1985) [Pubmed]
  4. A pilot study evaluating ceftriaxone and penicillin G as treatment agents for neurosyphilis in human immunodeficiency virus-infected individuals. Marra, C.M., Boutin, P., McArthur, J.C., Hurwitz, S., Simpson, P.A., Haslett, J.A., van der Horst, C., Nevin, T., Hook, E.W. Clin. Infect. Dis. (2000) [Pubmed]
  5. The cure of one of the most frequent types of dementia: a historical parallel. Nitrini, R. Alzheimer disease and associated disorders. (2005) [Pubmed]
  6. Minocycline for symptomatic neurosyphilis in patients allergic to penicillin. De Maria, A., Solaro, C., Abbruzzese, M., Primavera, A. N. Engl. J. Med. (1997) [Pubmed]
  7. The response of symptomatic neurosyphilis to high-dose intravenous penicillin G in patients with human immunodeficiency virus infection. Gordon, S.M., Eaton, M.E., George, R., Larsen, S., Lukehart, S.A., Kuypers, J., Marra, C.M., Thompson, S. N. Engl. J. Med. (1994) [Pubmed]
  8. Coma from long-term overingestion of isoniazid. Salkind, A.R., Hewitt, C.C. Arch. Intern. Med. (1997) [Pubmed]
  9. Acute syphilitic meningitis in a man with seropositivity for human immunodeficiency virus infection and normal numbers of CD4 T lymphocytes. DiNubile, M.J., Baxter, J.D., Mirsen, T.R. Arch. Intern. Med. (1992) [Pubmed]
  10. Neurosyphilis mimicking Miller-Fisher syndrome: a case report and MRI findings. Stepper, F., Schroth, G., Sturzenegger, M. Neurology (1998) [Pubmed]
  11. Erythromycin intravenous management in neurosyphilis. Lopez-Pousa, S., Manuel-Rimbau, J., Guerra, J.C., Torres, M.A. Neurology (1985) [Pubmed]
  12. Penetration of oral doxycycline into the cerebrospinal fluid of patients with latent or neurosyphilis. Yim, C.W., Flynn, N.M., Fitzgerald, F.T. Antimicrob. Agents Chemother. (1985) [Pubmed]
  13. Treatment of neurosyphilis with ceftriaxone. Shann, S., Wilson, J. Sexually transmitted infections. (2003) [Pubmed]
  14. A review and update on adult syphilis, with particular reference to its treatment. Goldmeier, D., Hay, P. International journal of STD & AIDS. (1993) [Pubmed]
  15. Unusual case report: three cases of psychiatric manifestations of neurosyphilis. Sobhan, T., Rowe, H.M., Ryan, W.G., Munoz, C. Psychiatric services (Washington, D.C.) (2004) [Pubmed]
  16. Penicillin-induced Jarisch-Herxheimer reaction. See, S., Scott, E.K., Levin, M.W. The Annals of pharmacotherapy. (2005) [Pubmed]
  17. Syphilis serology in human immunodeficiency virus-infected patients with symptomatic neurosyphilis: case report and review. Matlow, A.G., Rachlis, A.R. Rev. Infect. Dis. (1990) [Pubmed]
  18. Cerebrospinal fluid IgG changes in neurosyphilis after high-dose penicillin G treatment. Mazzarello, P., Poloni, M., Citterio, A., Camana, C., Ceroni, M. Arch. Neurol. (1987) [Pubmed]
  19. Relationship between neurological features and intrathecal synthesis of IgG antibodies to Treponema pallidum in untreated and treated human neurosyphilis. Prange, H.W., Moskophidis, M., Schipper, H.I., Müller, F. J. Neurol. (1983) [Pubmed]
  20. General paralysis of the insane associated with HLA-Aw32. Strandberg Pedersen, N., Axelsen, N.H., Svejgaard, A. Acta pathologica et microbiologica Scandinavica. Section C, Immunology. (1981) [Pubmed]
  21. Neurosyphilis in AIDS patients: initial CSF VDRL may be negative. Feraru, E.R., Aronow, H.A., Lipton, R.B. Neurology (1990) [Pubmed]
  22. Intractable epilepsy as the initial manifestation of neurosyphilis. Phan, T.G., Somerville, E.R., Chen, S. Epilepsia (1999) [Pubmed]
  23. Free light chains in the CSF in multiple sclerosis. Bracco, F., Gallo, P., Menna, R., Battistin, L., Tavolato, B. J. Neurol. (1987) [Pubmed]
  24. Reversible neurosyphilis presenting as chronic mania. Hoffman, B.F. The Journal of clinical psychiatry. (1982) [Pubmed]
  25. Neurosyphilis after treatment of latent syphilis with benzathine penicillin. Jørgensen, J., Tikjøb, G., Weismann, K. Genitourinary medicine. (1986) [Pubmed]
  26. The asymptomatic patient with a positive VDRL test. Feder, H.M., Manthous, C. American family physician. (1988) [Pubmed]
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