Disease relevance of Fluorescent Treponemal Antibody-Absorption Test

• Four hundred and forty-nine syphilis sera, positive in VDRL and FTA-ABS tests, were studied for the presence of circulating immune complexes (CIC) by means of anti-antibody (AA) neutralization test [1].
• Using 920 sera, we compared the specificity and reproducibility of the hemagglutination treponemal test for syphilis with those of the fluorescent treponemal antibody-absorption test and the microhemagglutination assay for Treponema pallidum antibodies; we found all three tests to be comparable [2].
• Seroreactivity of sera from 109 patients with first-infection primary syphilis was 98.2% in the fluorescent treponemal antibody absorption test, 92.7% in the rapid plasma reagin 18-mm circle card test, 72.5% in the microhemagglutination test (MHA-TP), and 72.5% in the Venereal Disease Research Laboratory test [3].
• Evaluation of sera from patients with Lyme disease in the fluorescent treponemal antibody-absorption test for syphilis [4].
• It appeared that the serological diagnosis of congenital syphilis must be based on the finding of specific neonatal antibodies in cord serum, which give positive results to the fluorescent treponemal antibody absorption test for immunoglobulin M, together with high titres of total IgM and negative results to latex tests [5].

High impact information on Fluorescent Treponemal Antibody-Absorption Test

• Thirty-seven patients (13%) had both reactive RPR and FTA-ABS tests [6].
• A double-staining procedure for the fluorescent treponemal antibody-absorption test, using fluorescein isothiocyanate as a label for the class-specific anti-human globulin and tetramethylrhodamine isothiocyanate as a label for a counterstain reagent, has been described [7].
• RESULTS: The diagnostic examination in most patients included serum angiotensin converting enzyme level, serum lysozyme, rapid plasma reagin level, fluorescent treponemal antibody-absorption test, purified protein derivative skin test, and chest x-rays [8].
• Incubation of treponemes with cardiolipin antibodies followed by a second incubation with treponemal specific antibodies resulted in a reduction of the titres of the FTA-ABS test and the TPI test [9].
• Increased sensitivity of the fluorescent treponemal antibody absorption test with biotin/avidin: a comparison with conventional FTA-ABS [10].

Associations of Fluorescent Treponemal Antibody-Absorption Test with chemical compounds

• All sera were also examined by traditional treponemal and cardiolipin tests and by the fluorescent treponemal antibody absorption (FTA-ABS) test for 19S(IgM) [11].

Gene context of Fluorescent Treponemal Antibody-Absorption Test

• A comparison has been made of the results of FTA-ABS tests with sorbent and Reiter sonicate and the TPI test on 1141 selected problem sera [12].
• To determine the incidence of positive serological findings in patients with sensorineural hearing loss, the rapid plasma reagin card test (RPRCT) and the FTA-ABS test were performed in a study group composed of patients with sensorineural hearing loss of obscure origin [13].
• Sensitivity of the CSF FTA-ABS test was higher (96%) than that of the CSF VDRL test (79%) [14].
• The two common treponemal tests are fluorescent treponemal antibody absorption test (FTA/ABS) and the Microhaemagglutination assay for Treponema pallidum (MHA-TP) [15].

Analytical, diagnostic and therapeutic context of Fluorescent Treponemal Antibody-Absorption Test

• The specificity of the fluorescent treponemal antibody-absorbed (FTA-Abs) test was assessed for 17 sera from syphilitic patients that were nonreactive in the Treponema pallidum immobilization (TPI) test but reactive in the FTA-Abs test [16].
• Results obtained with syphilitic and presumed non-syphilitic human sera were compared with results obtained in the absorbed fluorescent treponemal antibody test (FTA-ABS), the Reiter protein complement fixation test ( RPCFT ), the Venereal Diseases Research Laboratory Slide test (VDRL) and the Cardiolipin Wasserman reaction ( CWR ) [17].
• In sera from 476 diabetic outpatients, positive reaction in the Fluorescent Treponemal Antibody-Absorption (FTA-Abs) test, a commonly used serological test for syphilis, was found in 36 of the patients [18].

References