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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Dose and time related changes in LDH-X activity, epididymal carnitine levels and fertility, in gossypol-treated male rats.

Gossypol acetic acid could induce total infertility in male Wistar/NIN strain rats at a dose of 30 mg per kg body weight per day, for 52 days. 20 mg for 52 days and 30 mg for 38 days produced partial infertility. Highly significant correlation between parameters of infertility like reduced cauda sperm count, and implantation sites, and reduction in LDH-X activity of cauda epididymal sperm and carnitine levels in cauda epididymal fluid were observed. Testis remained unaffected.[1]

References

  1. Dose and time related changes in LDH-X activity, epididymal carnitine levels and fertility, in gossypol-treated male rats. Giridharan, N., Sesikeran, B., Bamji, M.S., Madhyastha, M.N. Contraception. (1987) [Pubmed]
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