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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Antibody response to sheep red blood cells in four substrains of BB rats, some other strains and interstrain F2 hybrids.

Primary and secondary antibody responses to SRBC were assayed in three substrains of dp BB rats, one strain of ndp BB rats, in their parental WOK rats, in highly inbred LEW rats, in two RT1 congenic strains LEW.1A and LEW.1W, and in the recombinant LEW.1WR2 strain. Furthermore, interstrain F1 and F2 hybrids of two dp BB substrains with congenic animals were tested. A significant lowering of the primary antibody response was found in two dp BB substrains and in the recombinant LEW.1WR2 strain. A transient lowering was shown in ndp BB rats. The third dp BB substrain responded well. The observed differences among three dp BB substrains only indicate that the level of antibody response to SRBC cannot be taken as a further marker, besides the RT1uv haplotype, for spontaneous development of the IDDM in BB rats. The observed decrease in the primary antibody response in the RT1 recombinant LEW.1WR2 rats and in one group of interstrain F2 hybrids typing as homozygous RT1uv may have another meaning. They could indicate some immunoregulatory effects of the RT1 haplotype on the supposedly multigenic response to SRBC in rats. No significant differences were found in the secondary antibody responses to SRBC.[1]


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