The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Gene Review

Im1  -  Immunoregulatory 1

Mus musculus

Synonyms: Im, Lch8-60
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Im1


Psychiatry related information on Im1

  • These data demonstrate that appropriate idiotypic exposure induces B and T cell responsiveness to the Ag recognized by the Id and support the hypothesis that neonatal idiotypic exposure can be an important immunoregulatory factor in schistosomiasis [6].
  • IL 1 is a major immunoregulatory molecule produced by macrophages, and it appears to be the molecular orchestrator of nonspecific host defense mechanisms against a variety of environmental insults [7].

High impact information on Im1


Chemical compound and disease context of Im1


Biological context of Im1

  • In a second backcross toward L line, the H line alleles of the putative Im genes on chromosomes 6, 8, and 12 were isolated from each other and their effects were still detected [18].
  • Previous examination of the antibodies produced by B-cell hybridomas derived from transgenic M54 mice showed that the presence of the mu transgene grossly altered the immunoglobulin repertoire of unimmunized animals, suggesting that these mice suffer from a serious immunoregulatory perturbation [19].
  • An immunoregulatory molecular complex with five active sites [20].
  • Combined with the insights provided by molecular genetic approaches and flow cytometry, functional and responsive lymphoid tumor cells are being used with increasing frequency to address basic immunoregulatory issues [21].
  • ILLs are believed to have immunoregulatory functions, but their roles in autoimmunity and defense against infections remain elusive [22].

Anatomical context of Im1


Associations of Im1 with chemical compounds

  • Vitamin A and retinoids are also known as potent immunoregulatory and antineoplastic agents [28].
  • Herein, we describe spontaneous tumor development in gene-targeted mice lacking interferon (IFN)-gamma and/or perforin (pfp), or the immunoregulatory cytokines, interleukin (IL)-12, IL-18, and tumor necrosis factor (TNF) [29].
  • Cellular and genetic restrictions in the immunoregulatory activity of alpha-fetoprotein. I. Selective inhibition of anti-Ia-associated proliferative reactions [30].
  • Epithelial-associated FcRn, through its ability to secrete and absorb IgG, may thus integrate luminal antigen encounters with systemic immune compartments and as such provide essential host defense and immunoregulatory functions at the mucosal surfaces [31].
  • Resistance is not a function of either low-dose irradiation- or cyclophosphamide (20 mg/kg)-sensitive immunoregulatory cells, but can be adoptively transferred by primed splenocytes [32].

Physical interactions of Im1


Regulatory relationships of Im1


Other interactions of Im1


Analytical, diagnostic and therapeutic context of Im1


  1. Tumour necrosis factor alpha restores granulomas and induces parasite egg-laying in schistosome-infected SCID mice. Amiri, P., Locksley, R.M., Parslow, T.G., Sadick, M., Rector, E., Ritter, D., McKerrow, J.H. Nature (1992) [Pubmed]
  2. Autoimmune dilated cardiomyopathy in PD-1 receptor-deficient mice. Nishimura, H., Okazaki, T., Tanaka, Y., Nakatani, K., Hara, M., Matsumori, A., Sasayama, S., Mizoguchi, A., Hiai, H., Minato, N., Honjo, T. Science (2001) [Pubmed]
  3. An interleukin (IL)-10/IL-12 immunoregulatory circuit controls susceptibility to autoimmune disease. Segal, B.M., Dwyer, B.K., Shevach, E.M. J. Exp. Med. (1998) [Pubmed]
  4. Transgenic interleukin 10 prevents induction of experimental autoimmune encephalomyelitis. Cua, D.J., Groux, H., Hinton, D.R., Stohlman, S.A., Coffman, R.L. J. Exp. Med. (1999) [Pubmed]
  5. Platelet-activating factor-mediated NF-kappaB dependency of a late anaphylactic reaction. Choi, I.W., Kim, Y.S., Kim, D.K., Choi, J.H., Seo, K.H., Im, S.Y., Kwon, K.S., Lee, M.S., Ha, T.Y., Lee, H.K. J. Exp. Med. (2003) [Pubmed]
  6. Neonatal exposure to idiotype induces Schistosoma mansoni egg antigen-specific cellular and humoral immune responses. Montesano, M.A., Colley, D.G., Freeman, G.L., Secor, W.E. J. Immunol. (1999) [Pubmed]
  7. Lyme disease spirochetes induce human and murine interleukin 1 production. Habicht, G.S., Beck, G., Benach, J.L., Coleman, J.L., Leichtling, K.D. J. Immunol. (1985) [Pubmed]
  8. The physiology of B cells as studied with tumor models. Hanley-Hyde, J.M., Lynch, R.G. Annu. Rev. Immunol. (1986) [Pubmed]
  9. Inhibition of indoleamine 2,3-dioxygenase, an immunoregulatory target of the cancer suppression gene Bin1, potentiates cancer chemotherapy. Muller, A.J., DuHadaway, J.B., Donover, P.S., Sutanto-Ward, E., Prendergast, G.C. Nat. Med. (2005) [Pubmed]
  10. Requirement for T-cell apoptosis in the induction of peripheral transplantation tolerance. Wells, A.D., Li, X.C., Li, Y., Walsh, M.C., Zheng, X.X., Wu, Z., Nuñez, G., Tang, A., Sayegh, M., Hancock, W.W., Strom, T.B., Turka, L.A. Nat. Med. (1999) [Pubmed]
  11. The receptor DEC-205 expressed by dendritic cells and thymic epithelial cells is involved in antigen processing. Jiang, W., Swiggard, W.J., Heufler, C., Peng, M., Mirza, A., Steinman, R.M., Nussenzweig, M.C. Nature (1995) [Pubmed]
  12. Effect of IFN-gamma on the immune response in vivo and on gene expression in vitro. Nakamura, M., Manser, T., Pearson, G.D., Daley, M.J., Gefter, M.L. Nature (1984) [Pubmed]
  13. Neutrophil granulocytes are required for effective bacillus calmette-guerin immunotherapy of bladder cancer and orchestrate local immune responses. Suttmann, H., Riemensberger, J., Bentien, G., Schmaltz, D., Stöckle, M., Jocham, D., Böhle, A., Brandau, S. Cancer Res. (2006) [Pubmed]
  14. 1alpha,25-Dihydroxyvitamin d3 has a direct effect on naive CD4(+) T cells to enhance the development of Th2 cells. Boonstra, A., Barrat, F.J., Crain, C., Heath, V.L., Savelkoul, H.F., O'Garra, A. J. Immunol. (2001) [Pubmed]
  15. Molecular evidence that granuloma T lymphocytes in murine schistosomiasis mansoni express an authentic substance P (NK-1) receptor. Cook, G.A., Elliott, D., Metwali, A., Blum, A.M., Sandor, M., Lynch, R., Weinstock, J.V. J. Immunol. (1994) [Pubmed]
  16. Prolonged lifespans in female NZB/NZW mice treated with the experimental immunoregulatory drug frentizole. Walker, S.E., Solsky, M., Schnitzer, B. Arthritis Rheum. (1982) [Pubmed]
  17. Probiotics ameliorate recurrent Th1-mediated murine colitis by inducing IL-10 and IL-10-dependent TGF-beta-bearing regulatory cells. Di Giacinto, C., Marinaro, M., Sanchez, M., Strober, W., Boirivant, M. J. Immunol. (2005) [Pubmed]
  18. Toward genetic dissection of high and low antibody responsiveness in Biozzi mice. Puel, A., Mevel, J.C., Bouthillier, Y., Feingold, N., Fridman, W.H., Mouton, D. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  19. Depletion of the predominant B-cell population in immunoglobulin mu heavy-chain transgenic mice. Herzenberg, L.A., Stall, A.M., Braun, J., Weaver, D., Baltimore, D., Herzenberg, L.A., Grosschedl, R. Nature (1987) [Pubmed]
  20. An immunoregulatory molecular complex with five active sites. Mitchison, N.A. Nature (1982) [Pubmed]
  21. Immunoglobulin-specific suppressor T cells. Lynch, R.G. Adv. Immunol. (1987) [Pubmed]
  22. Pivotal roles of CD8+ T cells restricted by MHC class I-like molecules in autoimmune diseases. Das, G., Das, J., Eynott, P., Zhang, Y., Bothwell, A.L., Kaer, L.V., Shi, Y. J. Exp. Med. (2006) [Pubmed]
  23. T cells with receptors for IgD. Coico, R.F., Xue, B., Wallace, D., Pernis, B., Siskind, G.W., Thorbecke, G.J. Nature (1985) [Pubmed]
  24. Local hormone networks and intestinal T cell homeostasis. Wang, J., Whetsell, M., Klein, J.R. Science (1997) [Pubmed]
  25. Immunoregulatory lymphokines of T hybridomas from AIDS patients: constitutive and inducible suppressor factors. Laurence, J., Mayer, L. Science (1984) [Pubmed]
  26. Suppressor T cell action inhibits the expression of an excluded immunoglobulin gene. Parslow, T.G., Milburn, G.L., Lynch, R.G., Granner, D.K. Science (1983) [Pubmed]
  27. CD4+ beta islet cell-reactive T cell clones that suppress autoimmune diabetes in nonobese diabetic mice. Akhtar, I., Gold, J.P., Pan, L.Y., Ferrara, J.L., Yang, X.D., Kim, J.I., Tan, K.N. J. Exp. Med. (1995) [Pubmed]
  28. T-cell-mediated enhancement of host-versus-graft reactivity in mice fed a diet enriched in vitamin A acetate. Malkovský, M., Edwards, A.J., Hunt, R., Palmer, L., Medawar, P.B. Nature (1983) [Pubmed]
  29. Suppression of lymphoma and epithelial malignancies effected by interferon gamma. Street, S.E., Trapani, J.A., MacGregor, D., Smyth, M.J. J. Exp. Med. (2002) [Pubmed]
  30. Cellular and genetic restrictions in the immunoregulatory activity of alpha-fetoprotein. I. Selective inhibition of anti-Ia-associated proliferative reactions. Peck, A.B., Murgita, R.A., Wigzell, H. J. Exp. Med. (1978) [Pubmed]
  31. Neonatal Fc receptor for IgG regulates mucosal immune responses to luminal bacteria. Yoshida, M., Kobayashi, K., Kuo, T.T., Bry, L., Glickman, J.N., Claypool, S.M., Kaser, A., Nagaishi, T., Higgins, D.E., Mizoguchi, E., Wakatsuki, Y., Roopenian, D.C., Mizoguchi, A., Lencer, W.I., Blumberg, R.S. J. Clin. Invest. (2006) [Pubmed]
  32. Multiple loci govern the bone marrow-derived immunoregulatory mechanism controlling dominant resistance to autoimmune orchitis. Meeker, N.D., Hickey, W.F., Korngold, R., Hansen, W.K., Sudweeks, J.D., Wardell, B.B., Griffith, J.S., Teuscher, C. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  33. Soluble interleukin 2 receptors are released from the cell surface of normal murine B lymphocytes stimulated with interleukin 5. Loughnan, M.S., Sanderson, C.J., Nossal, G.J. Proc. Natl. Acad. Sci. U.S.A. (1988) [Pubmed]
  34. Prostaglandin E2 receptors of the EP2 and EP4 subtypes regulate activation and differentiation of mouse B lymphocytes to IgE-secreting cells. Fedyk, E.R., Phipps, R.P. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  35. Modulation of inducible nitric oxide synthase induction by prostaglandin E2 in macrophages: distinct susceptibility in murine J774 and RAW 264.7 macrophages. Lin, W.W., Chen, B.C., Hsu, Y.W., Lee, C.M., Shyue, S.K. Prostaglandins Other Lipid Mediat. (1999) [Pubmed]
  36. Regulated expression and effect of galectin-1 on Trypanosoma cruzi-infected macrophages: modulation of microbicidal activity and survival. Zúñiga, E., Gruppi, A., Hirabayashi, J., Kasai, K.I., Rabinovich, G.A. Infect. Immun. (2001) [Pubmed]
  37. The IL-4 receptor alpha-chain-binding cytokines, IL-4 and IL-13, induce forkhead box P3-expressing CD25+CD4+ regulatory T cells from CD25-CD4+ precursors. Skapenko, A., Kalden, J.R., Lipsky, P.E., Schulze-Koops, H. J. Immunol. (2005) [Pubmed]
  38. Unique site of autoantibody production in Fas-deficient mice. Jacobson, B.A., Foote, L.C., Panka, D.J., Ju, S.T., Rothstein, T.L., Marshak-Rothstein, A. Ann. N. Y. Acad. Sci. (1997) [Pubmed]
  39. Interferon alpha/beta-mediated inhibition and promotion of interferon gamma: STAT1 resolves a paradox. Nguyen, K.B., Cousens, L.P., Doughty, L.A., Pien, G.C., Durbin, J.E., Biron, C.A. Nat. Immunol. (2000) [Pubmed]
  40. Aod1, the immunoregulatory locus controlling abrogation of tolerance in neonatal thymectomy-induced autoimmune ovarian dysgenesis, maps to mouse chromosome 16. Wardell, B.B., Michael, S.D., Tung, K.S., Todd, J.A., Blankenhorn, E.P., McEntee, K., Sudweeks, J.D., Hansen, W.K., Meeker, N.D., Griffith, J.S. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  41. Secretoglobins SCGB3A1 and SCGB3A2 define secretory cell subsets in mouse and human airways. Reynolds, S.D., Reynolds, P.R., Pryhuber, G.S., Finder, J.D., Stripp, B.R. Am. J. Respir. Crit. Care Med. (2002) [Pubmed]
  42. PU.1 and GATA: components of a mast cell-specific interleukin 4 intronic enhancer. Henkel, G., Brown, M.A. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  43. Expression of the p60 Autolysin Enhances NK Cell Activation and Is Required for Listeria monocytogenes Expansion in IFN-{gamma}-Responsive Mice. Humann, J., Bjordahl, R., Andreasen, K., Lenz, L.L. J. Immunol. (2007) [Pubmed]
  44. Dysregulation of IFN-gamma signaling pathways in the absence of TGF-beta 1. McCartney-Francis, N.L., Wahl, S.M. J. Immunol. (2002) [Pubmed]
  45. Role of the programmed death-1 pathway in regulation of alloimmune responses in vivo. Sandner, S.E., Clarkson, M.R., Salama, A.D., Sanchez-Fueyo, A., Domenig, C., Habicht, A., Najafian, N., Yagita, H., Azuma, M., Turka, L.A., Sayegh, M.H. J. Immunol. (2005) [Pubmed]
  46. Prolonged allograft survival in TNF receptor 1-deficient recipients is due to immunoregulatory effects, not to inhibition of direct antigraft cytotoxicity. McKee, C.M., Defina, R., He, H., Haley, K.J., Stone, J.R., Perkins, D.L. J. Immunol. (2002) [Pubmed]
  47. Targeted insertion of a variable region gene into the immunoglobulin heavy chain locus. Taki, S., Meiering, M., Rajewsky, K. Science (1993) [Pubmed]
  48. Immunoregulatory changes induced by total lymphoid irradiation. II. Development of thymus-leukemia antigen-positive and -negative suppressor T cells that differ in their regulatory function. King, D.P., Strober, S. J. Exp. Med. (1981) [Pubmed]
  49. Isolation and characterization of a distinct immunoregulatory isoform of alpha-fetoprotein produced by the normal fetus. van Oers, N.S., Cohen, B.L., Murgita, R.A. J. Exp. Med. (1989) [Pubmed]
WikiGenes - Universities