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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

[32P] diphosphonate dose determination in patients with bone metastases from prostatic carcinoma.

In an initial safety study, phosphorus-32 (as diphosphonate) was administered intravenously to five patients with painful bone metastases from prostatic carcinoma; two patients received 9 mCi and three were given 3 mCi. Hematological, biochemical, ECG, x-ray, bone-scan data, and clinical observation, were followed for 2 mo. At both dose levels, bone-marrow depression was noted. One of the patients, who received 9 mCi, had only a slight dip in the levels of circulating white blood cells and platelets. The other 9-mCi patient was the only one with discrete metastases by bone scan; he had bone-marrow depression, from which he recovered, and was the only one of the five who had relief of bone pain.[1]

References

  1. [32P] diphosphonate dose determination in patients with bone metastases from prostatic carcinoma. Potsaid, M.S., Irwin, R.J., Castronovo, F.P., Prout, G.R., Harvey, W.J., Francis, M.D., Tofe, A.J., Zamenhof, R.G. J. Nucl. Med. (1978) [Pubmed]
 
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