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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Nicotinamide adenine dinucleotide phosphate linked isocitrate dehydrogenase. Catalytic activation by the reduced coenzyme product of the reaction.

The oxidative decarboxylation of D-isocitrate catalyzed by NADP-linked isocitrate dehydrogenase is activated by NADPH, the product of the reaction. We analyzed the autocatalytic behavior exhibited by the enzyme during the steady-state kinetics. NADP acts as a competitive inhibitor toward NADPH in the catalytic activation. In a large concentration range of the reduced and oxidized coenzymes, the activity of the enzyme is proportional to the ratio (NADPH)/(NADP). The results are compared with the results of experiments done with other NADP-linked decarboxylating dehydrogenases. Two different models are presented in order to explain the mechanism of action of isocitrate dehydrogenase, according to our data.[1]


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