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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Cefmenoxime: in vitro activity.

The in vitro activity of cefmenoxime (SCE-1365 or A-50912), a new semisynthetic cephalosporin antibiotic, was determined for a broad spectrum of 1,234 organisms isolated as part of a multiclinic study. The minimum inhibitory concentration (MIC) of cefmenoxime required to inhibit at least 90 percent of strains tested (MIC90) ranged from 0.12 to 8 micrograms/ml for Enterobacteriaceae. MIC90S were 0.015 and 0.06 microgram/ml for Streptococcus pneumoniae and S. pyogenes, respectively, and 4 micrograms/ml for Staphylococcus aureus. Group D streptococci were less susceptible. The MIC90 of cefmenoxime for Neisseria gonorrhoeae and Hemophilus influenzae was 0.06 microgram/ml. Cefmenoxime was less active against Pseudomonas aeruginosa, Acinetobacter species, and Bacteroides fragilis (MIC50 = 16 micrograms/ml).[1]


  1. Cefmenoxime: in vitro activity. Stamm, J.M. Am. J. Med. (1984) [Pubmed]
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