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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Double-blind study to compare the selection of antibiotic resistance by amoxycillin or cephradine in the commensal flora.

Elderly patients with acute urinary infections were treated in a double-blind study with either amoxycillin or cephradine. In 52 patients who had received amoxycillin for one week about a third of all intestinal Escherichia coli were highly resistant to amoxycillin, and many were resistant to tetracycline, trimethoprim, or chloramphenicol. Cephradine selected less resistance. At a week after completion of chemotherapy, cephradine-resistant E coli were replaced by sensitive cultures at a greater frequency than were amoxycillin-resistant E coli. Neither antibiotic altered the skin flora. Amoxycillin, but not cephradine, selected for Enterobacteriaceae in the saliva. The propensity of amoxycillin to select resistance in E coli will limit its usefulness in treating urinary infections.[1]

References

  1. Double-blind study to compare the selection of antibiotic resistance by amoxycillin or cephradine in the commensal flora. Lacey, R.W., Lord, V.L., Howson, G.L., Luxton, D.E., Trotter, I.S. Lancet (1983) [Pubmed]
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