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Chemical Compound Review

Cefradine     (6R,7S)-7-[[(2R)-2-amino-2- (1-cyclohexa-1...

Synonyms: Cefradin, Cefradina, Cephradin, Velosef, Anspor, ...
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Disease relevance of Anspor


Psychiatry related information on Anspor

  • Thus a five-day regimen of cephradine, 500 mg BID, offers the potential advantages of cost-efficiency and improved patient compliance, while maintaining clinical efficacy in treating acute, uncomplicated urinary tract infections [6].

High impact information on Anspor


Chemical compound and disease context of Anspor


Biological context of Anspor


Anatomical context of Anspor

  • Eighty-eight female patients with a history of recurrent urinary tract infections were treated according to a randomization scheme with either 1 g of cephradine every 12 h (47 patients) or 375 mg of amoxicillin-clavulanate every 8 h (41 patients) for 7 days [17].
  • At various times before surgery, 33 patients undergoing coronary artery bypass or cardiac valve replacement surgery received a single 2.0-g dose of either cefazolin or cephradine [18].
  • Cephradine penetration into cerebrospinal fluid and effects of its administration into the cerebral ventricles of cats [19].
  • In the DEPC-pretreated membranes, the V(max) value of cephradine uptake was decreased without any change in the Km value [20].
  • The distribution of cephradine transport activity along the small intestine and villus-crypt axis was also examined in the isolated cells, and the transport activity was higher in the upper parts of the intestinal segments and in villus cells [21].

Associations of Anspor with other chemical compounds


Gene context of Anspor


Analytical, diagnostic and therapeutic context of Anspor

  • We report an isocratic "high-performance" liquid-chromatographic (HPLC) procedure for measurement of five orally administered cephalosporins (cefixime, cefaclor, cefadroxil, cephalexin, and cephradine) in 0.1 mL of human serum [32].
  • Concentrations of cephradine in blood were determined for 2 hr; the antibacterial activity was estimated from bacterial counts made in the homogenized individual thighs [33].
  • CAPD peritonitis: a prospective randomized trial of oral versus intraperitoneal treatment with cephradine [10].
  • Patients were randomly allocated to one of three groups: group 1 received no form of antibiotic prophylaxis; group 2 received 1 g of cephradine applied topically to the wound at closure; group 3 received 1 g of cephradine intravenously at induction of anaesthesia and a further intravenous dose of 500 mg 4 h later [34].
  • Three days after cardiac catheterization and prior to challenge with S. sanguis, rabbits received either 1000 mg/kg (ten animals) or 500 mg/kg cephradine intramuscularly [35].


  1. Cephradine-associated immune neutropenia. Lawson, A.A., McArdle, T., Ghosh, S. N. Engl. J. Med. (1985) [Pubmed]
  2. Letter: failure of cephradine in infective endocarditis. Daggett, P.R., Nathan, A.W. Lancet (1975) [Pubmed]
  3. Rational choice of penicillins and cephalosporins based on parallel in-vitro and in-vivo tests. Selwyn, S. Lancet (1976) [Pubmed]
  4. Double-blind study to compare the selection of antibiotic resistance by amoxycillin or cephradine in the commensal flora. Lacey, R.W., Lord, V.L., Howson, G.L., Luxton, D.E., Trotter, I.S. Lancet (1983) [Pubmed]
  5. Cefazolin and cephradine: relationship between antibacterial activity in vitro and in mice experimentally infected with Escherichia coli. Kunst, M.W., Mattie, H. J. Infect. Dis. (1978) [Pubmed]
  6. Five-day therapy with cephradine capsules, 500 mg BID, for the treatment of acute, uncomplicated urinary tract infections. Brosof, A.B. Clinical therapeutics. (1980) [Pubmed]
  7. H+ coupled uphill transport of aminocephalosporins via the dipeptide transport system in rabbit intestinal brush-border membranes. Okano, T., Inui, K., Maegawa, H., Takano, M., Hori, R. J. Biol. Chem. (1986) [Pubmed]
  8. Sex differences in the intramuscular absorption and bioavailability of cephradine. Vukovich, R.A., Brannick, L.J., Sugerman, A.A., Neiss, E.S. Clin. Pharmacol. Ther. (1975) [Pubmed]
  9. Short-term adverse effects of antibiotic prophylaxis for open-heart surgery. Freeman, R. Thorax (1980) [Pubmed]
  10. CAPD peritonitis: a prospective randomized trial of oral versus intraperitoneal treatment with cephradine. Boeschoten, E.W., Rietra, P.J., Krediet, R.T., Visser, M.J., Arisz, L. J. Antimicrob. Chemother. (1985) [Pubmed]
  11. In vitro combination of mecillinam with cephradine or amoxycillin for organisms resistant to single agents. Chattopadhyay, B., Hall, I. J. Antimicrob. Chemother. (1979) [Pubmed]
  12. Roxithromycin, a new macrolide antibiotic, in the treatment of infections in the lower respiratory tract: an overview. Gentry, L.O. J. Antimicrob. Chemother. (1987) [Pubmed]
  13. Comparative study of cefaclor and amoxicillin in treatment of urinary tract infection. Rotschafer, J., Crossley, K., Zaske, D., Viste, R. Urology (1979) [Pubmed]
  14. Pharmacokinetics of cephradine suspension infants and children. Ginsburg, C.M., McCracken, G.H. Antimicrob. Agents Chemother. (1979) [Pubmed]
  15. Comparison of the pharmacokinetics of cephradine and cefazolin in pregnant and non-pregnant women. Philipson, A., Stiernstedt, G., Ehrnebo, M. Clinical pharmacokinetics. (1987) [Pubmed]
  16. Penetration of cephradine into heart valves, subcutaneous tissue and muscle of patients undergoing open heart surgery. Daschner, F.D., Langmaack, H., Spillner, G., Ahmadi, A., Schlosser, V. J. Antimicrob. Chemother. (1979) [Pubmed]
  17. Comparative study of cephradine and amoxicillin-clavulanate in the treatment of recurrent urinary tract infections. Brumfitt, W., Hamilton-Miller, J.M. Antimicrob. Agents Chemother. (1990) [Pubmed]
  18. Effect of protein binding on the penetration of nonmetabolized cephalosporins into atrial appendage and pericardial fluids in open-heart surgical patients. Nightingale, C.H., Klimek, J.J., Quintiliani, R. Antimicrob. Agents Chemother. (1980) [Pubmed]
  19. Cephradine penetration into cerebrospinal fluid and effects of its administration into the cerebral ventricles of cats. Harik, S.I., Akl, K.F., Uwaydah, M. Antimicrob. Agents Chemother. (1977) [Pubmed]
  20. Effect of various chemical modifiers on H+ coupled transport of cephradine via dipeptide carriers in rabbit intestinal brush-border membranes: role of histidine residues. Kato, M., Maegawa, H., Okano, T., Inui, K., Hori, R. J. Pharmacol. Exp. Ther. (1989) [Pubmed]
  21. Transport of oral cephalosporins by the H+/dipeptide cotransporter and distribution of the transport activity in isolated rabbit intestinal epithelial cells. Tomita, Y., Takano, M., Yasuhara, M., Hori, R., Inui, K. J. Pharmacol. Exp. Ther. (1995) [Pubmed]
  22. Cephalosporins in urinary tract infection. Gentry, L.O. Drugs (1987) [Pubmed]
  23. Comparison of in vitro antibacterial activity of three oral cephalosporins: cefaclor, cephalexin, and cephradine. Silver, M.S., Counts, G.W., Zeleznik, D., Turck, M. Antimicrob. Agents Chemother. (1977) [Pubmed]
  24. Effect of amoxicillin-clavulanate and cephradine on the fecal flora of healthy volunteers not exposed to a hospital environment. Brumfitt, W., Franklin, I., Grady, D., Hamilton-Miller, J.M. Antimicrob. Agents Chemother. (1986) [Pubmed]
  25. Cefadroxil. A review of its antibacterial, pharmacokinetic and therapeutic properties in comparison with cephalexin and cephradine. Tanrisever, B., Santella, P.J. Drugs (1986) [Pubmed]
  26. Binding of amino beta-lactam antibiotics to soluble protein from rat intestinal mucosa--II. Mutual inhibition of binding among amino beta-lactam antibiotics and binding characteristics. Iseki, K., Mori, K., Miyazaki, K., Arita, T. Biochem. Pharmacol. (1987) [Pubmed]
  27. Identification of the histidine residues involved in substrate recognition by a rat H+/peptide cotransporter, PEPT1. Terada, T., Saito, H., Mukai, M., Inui, K.I. FEBS Lett. (1996) [Pubmed]
  28. Variation of peptide transporter (PepT1 and HPT1) expression in Caco-2 cells as a function of cell origin. Behrens, I., Kamm, W., Dantzig, A.H., Kissel, T. Journal of pharmaceutical sciences. (2004) [Pubmed]
  29. Preparation and characterization of porous hollow silica nanoparticles for drug delivery application. Chen, J.F., Ding, H.M., Wang, J.X., Shao, L. Biomaterials (2004) [Pubmed]
  30. Reversed-phase high-performance liquid chromatography of amphoteric beta-lactam antibiotics: effects of columns, ion-pairing reagents and mobile phase pH on their retention times. Huang, H.S., Wu, J.R., Chen, M.L. J. Chromatogr. (1991) [Pubmed]
  31. Pseudomembranous colitis associated with antibiotic prophylaxis in orthopaedic surgery. Cannon, S.R., Dyson, P.H., Sanderson, P.J. The Journal of bone and joint surgery. British volume. (1988) [Pubmed]
  32. Liquid-chromatographic determination of five orally active cephalosporins--cefixime, cefaclor, cefadroxil, cephalexin, and cephradine--in human serum. McAteer, J.A., Hiltke, M.F., Silber, B.M., Faulkner, R.D. Clin. Chem. (1987) [Pubmed]
  33. Probenecid and the antibacterial activity of cephradine in vivo. Kunst, M.W., Mattie, H. J. Infect. Dis. (1978) [Pubmed]
  34. Wound sepsis following gastrointestinal surgery: a comparison of topical and two-dose systemic cephradine. Finch, D.R., Taylor, L., Morris, P.J. The British journal of surgery. (1979) [Pubmed]
  35. One and two doses of cephradine in the prophylaxis of experimental streptococcal endocarditis. Longman, L.P., Martin, M.V., Smalley, J.W. J. Antimicrob. Chemother. (1987) [Pubmed]
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