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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Displacement of serotonin from binding sites in rat cortex: the effects of biogenic "trace" amines.

The concentrations for 50 percent inhibition of binding (IC50's) to specific in vitro serotonin binding sites (5-HT1 and 5-HT2) of rat cerebral cortex were determined for the trace amines 2-phenylethylamine, m- and p-tyramine, tryptamine, and (+)- and (-)- alpha-methyltryptamine. Tryptamine gave an IC50 of 66.7 +/- 4.8 nM (n = 7) at the 5-HT1 site and an IC50 of 3.85 +/- 0.16 microM (n = 7) for the 5-HT2 binding site. The IC50 values for all the other compounds were in the micromolar range and were different at the two binding sites except for p-tyramine (IC50, 5-HT1 = IC50, 5-HT2 = 17 microM. The trace amines may have different functional roles as evidenced by their different degrees of displacement of serotonin at 5-HT1 and 5-HT2 binding sites in the brain.[1]

References

  1. Displacement of serotonin from binding sites in rat cortex: the effects of biogenic "trace" amines. Locock, R.A., Baker, G.B., Coutts, R.T., Dewhurst, W.G. Prog. Neuropsychopharmacol. Biol. Psychiatry (1984) [Pubmed]
 
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