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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Biologic properties of three newly established human esophageal carcinoma cell lines.

Three epithelial cell lines, CE- 48T/VGH, CE-69T/-VGH, and CE-81T/VGH, were established from human squamous cell carcinoma of the esophagus. The cells were polygonal with a high nucleus-to-cytoplasm ratio. Many cells were multinucleate. Electron microscopy revealed the presence of tonofilaments and desmosomes. Chromosome analysis showed that these 3 cell lines were heteroploids of human origin. When transplanted into BALB/c (nu/nu) mice, CE-69T/VGH and CE-81T/VGH produced tumors, the histology of which proved to be carcinomas. All 3 cell lines secreted carcinoembryonic antigen. However, the secretion patterns were different. These 3 cell lines may provide useful models for the study of human esophageal cancer.[1]

References

  1. Biologic properties of three newly established human esophageal carcinoma cell lines. Hu, C.P., Hsieh, H.G., Chien, K.Y., Wang, P.Y., Wang, C.I., Chen, C.Y., Lo, S.J., Wuu, K.D., Chang, C.M. J. Natl. Cancer Inst. (1984) [Pubmed]
 
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